PIPA589617
Claudin 2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589617-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA589617 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Claudin 2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CLDN2
Gene Alias
AL022813, claudin 2, Claudin2, claudin-2, CLD2, Cldn2, integral membrane protein claudin-2, PSEC0059, RGD1560247, SP82, UNQ705/PRO1356
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12738, 300920, 9075
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.83 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
O88552, P57739
Gene Symbols
CLDN2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 184-230 of human CLDN2 (NP_0011645631)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Positive Samples: Mouse liver, Mouse lung; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction Immunogen sequence: SCSSQRNRSN YYDAYQAQPL ATRSSPRPGQ PPKVKSEFNS YSLTGYV Tight junctions are specialized regions of cell-cell contact that are particularly abundant in luminal epithelial cell sheets
- In freeze-fracture electron micrographs, tight junctions are visualized as belt-like bands of anastomosing sealing strands (TJ strands) that completely encircle the lateral surfaces of each cell
- TJ strands on adjacent cells are presumed to interact with each other to form a sort of "emolecular gasket"e that prevents ions, water and other molecules from leaking between cells and thus, from one side of the sheet to the other
- In addition to this so-called "ebarrier"e function, the "efence"e function of tight junctions plays an important role in maintaining epithelial cell-polarity by blocking the diffusion of membrane proteins between apical (luminal) and basolateral cell surfaces
- Confinement of, for example, the glucose symport to apical surfaces allows glucose to be transported vectorially from the lumen, through the cell, and into the bloodstream
- Several peripheral membrane proteins are associated with tight junctions including ZO-1, ZO-2, ZO-3 (members of membrane-associated guanylate-kinase family), cingulin, the 7H6 antigen, Rab-3b, symplekin
- While their precise functions are not known, roles for these proteins have been suggested in tight junction assembly and maintenance; signal transduction; and the regulation of tight junction permeability
- Furthermore, a growing body of evidence suggests that actin filaments play a major role in regulating tight junction permeability
- Until recently, the only transmembrane protein known to be associated with tight junctions was occludin, an ∽65 kDa protein with four transmembrane domains
- Despite widespread expectation, a critical structural role for occludin in TJ strands was ruled out by the observation of apparently normal tight junctions formed between cells disrupted at both occludin alleles
- Fortunately, a closer examination of isolated tight junctions uncovered two related ∽22 kDa, four-transmembrane domain proteins, claudin-1 and claudin-2, with no similarity to occludin
- In contrast to occludin, which induces only a small number of short strands at cell-cell contact sites when introduced into fibroblasts lacking tight junctions, claudin-1 and -2 induce networks of strands characteristic of true tight junctions
- Though inconclusive, these findings suggest that claudin-1 and -2 are major structural components of TJ strands and that occludin plays some other accessory role
- Excitement in the tight junction field continues to rise following the recent discovery of claudins -3, -4, -5, -6, -7, and -8 and experiments suggesting that tight junctions in different tissues are comprised of different sets of claudin family proteins
- Claudin-1 and claudin-2 connect to the actin cytoskeleton through ZO-1; Claudin-2 functions as a paracellular channel with cation (Na+) selectivity at tight junctions
- The expression of claudin-2 is restricted to the liver and kidney, with small amounts also found in the brain.
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Antigen: Claudin 2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CLDN2
Gene Alias: AL022813, claudin 2, Claudin2, claudin-2, CLD2, Cldn2, integral membrane protein claudin-2, PSEC0059, RGD1560247, SP82, UNQ705/PRO1356
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12738, 300920, 9075
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.83 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: O88552, P57739
Gene Symbols: CLDN2
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 184-230 of human CLDN2 (NP_0011645631)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Claudin 2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CLDN2
Gene Alias:
AL022813, claudin 2, Claudin2, claudin-2, CLD2, Cldn2, integral membrane protein claudin-2, PSEC0059, RGD1560247, SP82, UNQ705/PRO1356
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12738, 300920, 9075
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.83 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
O88552, P57739
Gene Symbols:
CLDN2
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 184-230 of human CLDN2 (NP_0011645631)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: FXR2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FXR2
Gene Alias: FMR1 autosomal homolog 2, FMR1L2, fragile X mental retardation gene 2, autosomal homolog, fragile X mental retardation syndrome-related protein 2, fragile X mental retardation, autosomal homolog 2, fragile X mental retardation-related protein 2, fragile X-mental retardation 1-like 2, Fxr2, Fxr2h, FXR2P
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23879, 287433, 9513
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.834 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P51116, Q9WVR4
Gene Symbols: FXR2
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_0048512)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
FXR2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FXR2
Gene Alias:
FMR1 autosomal homolog 2, FMR1L2, fragile X mental retardation gene 2, autosomal homolog, fragile X mental retardation syndrome-related protein 2, fragile X mental retardation, autosomal homolog 2, fragile X mental retardation-related protein 2, fragile X-mental retardation 1-like 2, Fxr2, Fxr2h, FXR2P
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23879, 287433, 9513
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.834 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P51116, Q9WVR4
Gene Symbols:
FXR2
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_0048512)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: GLYAT
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GLYAT
Gene Alias: A330009E03Rik, AAc, Ab2-132, ACGNAT, Acyl-CoA:glycine N-acyltransferase, AI195249, AI315345, Aralkyl acyl-CoA N-acyltransferase, aralkyl acyl-CoA:amino acid N-acyltransferase, aralkyl-CoA N-acyltransferase, benzoyl-coenzyme A:glycine N-acyltransferase, CAT, GAT, Glyat, Glycine N-acyltransferase, glycine N-benzoyltransferase, glycine-N-acyltransferase, HRP-1(CLP), Liver regeneration-related protein LRRG067
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 107146, 293779
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.98 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: Q5PQT3, Q91XE0
Gene Symbols: GLYAT
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human GLYAT (NP_0058293)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
GLYAT
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GLYAT
Gene Alias:
A330009E03Rik, AAc, Ab2-132, ACGNAT, Acyl-CoA:glycine N-acyltransferase, AI195249, AI315345, Aralkyl acyl-CoA N-acyltransferase, aralkyl acyl-CoA:amino acid N-acyltransferase, aralkyl-CoA N-acyltransferase, benzoyl-coenzyme A:glycine N-acyltransferase, CAT, GAT, Glyat, Glycine N-acyltransferase, glycine N-benzoyltransferase, glycine-N-acyltransferase, HRP-1(CLP), Liver regeneration-related protein LRRG067
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
107146, 293779
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.98 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
Q5PQT3, Q91XE0
Gene Symbols:
GLYAT
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human GLYAT (NP_0058293)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: STIP1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STIP1
Gene Alias: epididymis secretory sperm binding protein Li 94n, HEL-S-94n, HOP, hsc70/Hsp90-organizing protein, Hsp70/Hsp90 organizing protein, Hsp70/Hsp90-organizing protein, IEF SSP 3521, IEF-SSP-3521, mSTI1, NY-REN-11 antigen, P60, Renal carcinoma antigen NY-REN-11, STI1, STI1L, Stip1, stress induced phosphoprotein 1, stress-induced phosphoprotein 1, stress-induced-phosphoprotein 1, stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein), stress-inducible protein, transformation-sensitive protein IEF SSP 3521
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10963, 192277, 20867
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 0.23 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: O35814, P31948, Q60864
Gene Symbols: STIP1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STIP1 (NP_0068101)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
STIP1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STIP1
Gene Alias:
epididymis secretory sperm binding protein Li 94n, HEL-S-94n, HOP, hsc70/Hsp90-organizing protein, Hsp70/Hsp90 organizing protein, Hsp70/Hsp90-organizing protein, IEF SSP 3521, IEF-SSP-3521, mSTI1, NY-REN-11 antigen, P60, Renal carcinoma antigen NY-REN-11, STI1, STI1L, Stip1, stress induced phosphoprotein 1, stress-induced phosphoprotein 1, stress-induced-phosphoprotein 1, stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein), stress-inducible protein, transformation-sensitive protein IEF SSP 3521
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10963, 192277, 20867
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
0.23 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
O35814, P31948, Q60864
Gene Symbols:
STIP1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STIP1 (NP_0068101)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG