PIPA594956
Caspase 8 p18 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA594956-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA594956 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Caspase 8 p18
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Casp8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, caspase-8, Caspase-8 subunit p10, Caspase-8 subunit p18, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MORT1-associated ced-3 homolog
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12370, 64044, 841
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Applications
Western Blot
Concentration
500 μg/mL
Formulation
PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.
O89110, Q14790, Q9JHX4
Gene Symbols
Casp8
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Caspase-8 (P18) (240-259aa DKVYQMKSKPRGYCLIINNH).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL
- Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
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Antigen: Caspase 8 p18
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Casp8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, caspase-8, Caspase-8 subunit p10, Caspase-8 subunit p18, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MORT1-associated ced-3 homolog
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12370, 64044, 841
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.: O89110, Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Caspase-8 (P18) (240-259aa DKVYQMKSKPRGYCLIINNH).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8 p18
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Casp8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, caspase-8, Caspase-8 subunit p10, Caspase-8 subunit p18, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MORT1-associated ced-3 homolog
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12370, 64044, 841
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.:
O89110, Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Caspase-8 (P18) (240-259aa DKVYQMKSKPRGYCLIINNH).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospholamban
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PLN
Gene Alias: cardiac CMH18, Cardiac phospholamban, CMD1P, CMH18, phospholamban, Plb, Plm, PLN, unnamed protein product
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5350, 64672
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.: P26678, P61016
Gene Symbols: PLN
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PLN (2-16aa EKVQYLTRSAIRRAS).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospholamban
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PLN
Gene Alias:
cardiac CMH18, Cardiac phospholamban, CMD1P, CMH18, phospholamban, Plb, Plm, PLN, unnamed protein product
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5350, 64672
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.:
P26678, P61016
Gene Symbols:
PLN
Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human PLN (2-16aa EKVQYLTRSAIRRAS).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SNAP25
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Snap25
Gene Alias: ALMS1, bA416N4.2, Bdr, blind drunk, CG17676, CG17884, CG40452, CMS18, dJ1068F16.2, Dmel CG40452, Dmel_CG40452, etID17571.20, etID69167.20, fj42b02, fj45g04, fj48c02, FLJ23079, GENA70, HGNC:11132, resistance to inhibitors of cholinesterase 4 homolog, RIC4, RIC-4, SEC9, si:dkeyp-8f4.6, Snap, SNAP 25, snap25, SNAP-25, snap25.1, SNAP-25.1, snap25a, SNAP-25A, SNAP-25B, snp25, sp, SUP, super protein, synaptosomal associated protein-25, synaptosomal-associated 25 kDa protein, Synaptosomal-associated protein 25, synaptosomal-associated protein 25-A, synaptosomal-associated protein, 25 kDa, synaptosomal-associated protein, 25a, synaptosomal-associated protein, 25kDa, synaptosome associated protein 25, synaptosome associated protein 25a, synaptosome associated protein 25kDa, synaptosome-associated protein 25.1, synaptosome-associated protein 25a, wu:fj42b02, wu:fj45g04, wu:fj48c02
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20614, 25012, 6616
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.: P60879, P60880, P60881
Gene Symbols: Snap25
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP25 (186-200aa DSNKTRIDEANQRAT).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SNAP25
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Snap25
Gene Alias:
ALMS1, bA416N4.2, Bdr, blind drunk, CG17676, CG17884, CG40452, CMS18, dJ1068F16.2, Dmel CG40452, Dmel_CG40452, etID17571.20, etID69167.20, fj42b02, fj45g04, fj48c02, FLJ23079, GENA70, HGNC:11132, resistance to inhibitors of cholinesterase 4 homolog, RIC4, RIC-4, SEC9, si:dkeyp-8f4.6, Snap, SNAP 25, snap25, SNAP-25, snap25.1, SNAP-25.1, snap25a, SNAP-25A, SNAP-25B, snp25, sp, SUP, super protein, synaptosomal associated protein-25, synaptosomal-associated 25 kDa protein, Synaptosomal-associated protein 25, synaptosomal-associated protein 25-A, synaptosomal-associated protein, 25 kDa, synaptosomal-associated protein, 25a, synaptosomal-associated protein, 25kDa, synaptosome associated protein 25, synaptosome associated protein 25a, synaptosome associated protein 25kDa, synaptosome-associated protein 25.1, synaptosome-associated protein 25a, wu:fj42b02, wu:fj45g04, wu:fj48c02
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20614, 25012, 6616
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.:
P60879, P60880, P60881
Gene Symbols:
Snap25
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP25 (186-200aa DSNKTRIDEANQRAT).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cytokeratin 19
Classification: Polyclonal
Conjugate: Unconjugated
Gene: KRT19
Gene Alias: 40-kDa keratin intermediate filament, AI663979, C K1CS, CK 19, CK19, CK-19, cytokeratin 19, cytokeratin-19, EndoC, K19, K1CS, Ka19, keratin 19, keratin 19, type I, keratin complex 1, acidic, gene 19, keratin, type I cytoskeletal 19, keratin, type I, 40-kd, keratin-19, Krt-1.19, Krt1-19, Krt19, LOC100344434, MGC15366, Type I keratin Ka19
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3880
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.: P08727
Gene Symbols: KRT19
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cytokeratin 19 (379-392aa YRSLLEGQEDHYNN).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Cytokeratin 19
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
KRT19
Gene Alias:
40-kDa keratin intermediate filament, AI663979, C K1CS, CK 19, CK19, CK-19, cytokeratin 19, cytokeratin-19, EndoC, K19, K1CS, Ka19, keratin 19, keratin 19, type I, keratin complex 1, acidic, gene 19, keratin, type I cytoskeletal 19, keratin, type I, 40-kd, keratin-19, Krt-1.19, Krt1-19, Krt19, LOC100344434, MGC15366, Type I keratin Ka19
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3880
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
Gene Accession No.:
P08727
Gene Symbols:
KRT19
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Cytokeratin 19 (379-392aa YRSLLEGQEDHYNN).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG