PIPA595427
Survivin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595427-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA595427 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Survivin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Birc5
Gene Alias
AAC-11, AP14, Api4, apoptosis inhibitor 4, Apoptosis inhibitor survivin, baculoviral IAP repeat containing 5, baculoviral IAP repeat-containing 5, baculoviral IAP repeat-containing 5 (survivin), baculoviral IAP repeat-containing protein 5, BIRC 5, BIRC5, EPR 1, EPR-1, Iap4, inhibitor of apoptosis, survivin, survivin variant 3 alpha, survivin40, SVV, TIAP
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11799, 332, 64041
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Applications
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration
500 μg/mL
Formulation
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.
O15392, O70201, Q9JHY7
Gene Symbols
Birc5
Immunogen
E.coli-derived human Survivin recombinant protein (Position: M1-D142).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Human Survivin shares 84.3% and 83% amino acid (aa) sequence identity with mouse and rat Survivin, respectively
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL
- Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family
- The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues
- IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain
- The encoded proteins also lack a C-terminus RING finger domain
- Gene expression is high during fetal development and in most tumors yet low in adult tissues
- Antisense transcripts are involved in the regulation of survivin’s gene expression
- Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner
- At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics
- Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis
- Survivin may counteract a default induction of apoptosis in G2/M phase
- Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury
- Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein)
- Survivin might affect regulation of neural cell proliferative responses after brain injury
- At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined
- The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
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Antigen: Survivin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Birc5
Gene Alias: AAC-11, AP14, Api4, apoptosis inhibitor 4, Apoptosis inhibitor survivin, baculoviral IAP repeat containing 5, baculoviral IAP repeat-containing 5, baculoviral IAP repeat-containing 5 (survivin), baculoviral IAP repeat-containing protein 5, BIRC 5, BIRC5, EPR 1, EPR-1, Iap4, inhibitor of apoptosis, survivin, survivin variant 3 alpha, survivin40, SVV, TIAP
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11799, 332, 64041
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.: O15392, O70201, Q9JHY7
Gene Symbols: Birc5
Immunogen: E.coli-derived human Survivin recombinant protein (Position: M1-D142).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Survivin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Birc5
Gene Alias:
AAC-11, AP14, Api4, apoptosis inhibitor 4, Apoptosis inhibitor survivin, baculoviral IAP repeat containing 5, baculoviral IAP repeat-containing 5, baculoviral IAP repeat-containing 5 (survivin), baculoviral IAP repeat-containing protein 5, BIRC 5, BIRC5, EPR 1, EPR-1, Iap4, inhibitor of apoptosis, survivin, survivin variant 3 alpha, survivin40, SVV, TIAP
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11799, 332, 64041
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.:
O15392, O70201, Q9JHY7
Gene Symbols:
Birc5
Immunogen:
E.coli-derived human Survivin recombinant protein (Position: M1-D142).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD105
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ENG
Gene Alias: AI528660, AI662476, CD105, CD105 antigen, cell surface MJ7/18 antigen, Edg, END, Endo, Endoglin, endoglin (Osler-Rendu-Weber syndrome 1), Eng, HHT1, ORW, ORW1, S-endoglin, transmembrane glycoprotein
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2022
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Flow Cytometry, Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 4MG trehalose and no preservative
Gene Accession No.: P17813
Gene Symbols: ENG
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CD105 (258-297aa YVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQ).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
CD105
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ENG
Gene Alias:
AI528660, AI662476, CD105, CD105 antigen, cell surface MJ7/18 antigen, Edg, END, Endo, Endoglin, endoglin (Osler-Rendu-Weber syndrome 1), Eng, HHT1, ORW, ORW1, S-endoglin, transmembrane glycoprotein
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2022
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Flow Cytometry, Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 4MG trehalose and no preservative
Gene Accession No.:
P17813
Gene Symbols:
ENG
Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human CD105 (258-297aa YVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQ).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: ECE1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ECE1
Gene Alias: AW322500, Ece, ECE 1, ECE1, ECE-1, ECE-1a, ECE-1b, ECE-1d, endothelin converting enzyme 1, endothelin-converting enzyme 1, endothelin-converting enzyme-1a, endothelin-converting enzyme-1b, endothelin-converting enzyme-1d
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1889, 230857, 94204
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.: P42892, P42893, Q4PZA2
Gene Symbols: ECE1
Immunogen: E.coli-derived human ECE1 recombinant protein (Position: M18-T233).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ECE1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ECE1
Gene Alias:
AW322500, Ece, ECE 1, ECE1, ECE-1, ECE-1a, ECE-1b, ECE-1d, endothelin converting enzyme 1, endothelin-converting enzyme 1, endothelin-converting enzyme-1a, endothelin-converting enzyme-1b, endothelin-converting enzyme-1d
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1889, 230857, 94204
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.:
P42892, P42893, Q4PZA2
Gene Symbols:
ECE1
Immunogen:
E.coli-derived human ECE1 recombinant protein (Position: M18-T233).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: IL-2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: IL2
Gene Alias: aldesleukin, cytokine, H-IL-2, il 2, Il2, Il-2, ILN, Interleukin, interleukin 2, interleukin 2 precursor, interleukin 2 variant IL2delta2, Interleukin2, Interleukin-2, interleukin-2 precursor, interleukin-2 precursor protein, interleukin-2, interleukin 2, Involved in regulation of T cell clonal expansion, involved in regulation of T-cell clonal expansion, lymphokine, M-IL-2, patial sequence of Interleukin-2, POIL2, porcine Interleukin 2, T cell growth factor, T-cell growth factor, T-cell growth factor (TCGF), TCGF
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3558
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: ELISA, Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.: P60568
Gene Symbols: IL2
Immunogen: E.coli-derived human IL-2 recombinant protein (Position: A21-T153).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
IL-2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
IL2
Gene Alias:
aldesleukin, cytokine, H-IL-2, il 2, Il2, Il-2, ILN, Interleukin, interleukin 2, interleukin 2 precursor, interleukin 2 variant IL2delta2, Interleukin2, Interleukin-2, interleukin-2 precursor, interleukin-2 precursor protein, interleukin-2, interleukin 2, Involved in regulation of T cell clonal expansion, involved in regulation of T-cell clonal expansion, lymphokine, M-IL-2, patial sequence of Interleukin-2, POIL2, porcine Interleukin 2, T cell growth factor, T-cell growth factor, T-cell growth factor (TCGF), TCGF
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3558
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
ELISA, Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.:
P60568
Gene Symbols:
IL2
Immunogen:
E.coli-derived human IL-2 recombinant protein (Position: A21-T153).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG