PIPA595820
GRK2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595820-Each-of-1 | In Stock | ₹ 49,528.50 |
PIPA595820 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,528.50
GST (18%): ₹ 8,915.13
Total Price: ₹ 58,443.63
Antigen
GRK2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GRK2
Gene Alias
ADRBK1, Adrbk-1, adrenergic beta receptor kinase 1, adrenergic receptor kinase, beta 1, adrenergic, beta, receptor kinase 1, BARK, BARK1, Bark-1, beta ARK, Beta-adrenergic receptor kinase 1, beta-adrenergic receptor kinase 1 beta ARK1, beta-AR kinase-1, betaARK1, BETA-ARK1, beta-ARK-1, EC 2.7.1.126, G protein-coupled receptor kinase 2, G-protein coupled receptor kinase 2, G-protein-coupled receptor kinase 2, grk 2, Grk2, GRK-2
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
110355, 156, 25238
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.12 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
P25098, P26817, Q99MK8
Gene Symbols
GRK2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 440-689 of human GRK2 (NP_0016102)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: LGRGAQEVKE SPFFRSLDWQ MVFLQKYPPP LIPPRGEVNA ADAFDIGSFD EEDTKGIKLL DSDQELYRNF PLTISERWQQ EVAETVFDTI NAETDRLEAR KKAKNKQLGH EEDYALGKDC IMHGYMSKMG NPFLTQWQRR YFYLFPNRLE WRGEGEAPQS LLTMEEIQSV EETQIKERKC LLLKIRGGKQ FILQCDSDPE LVQWKKELRD AYREAQQLVQ RVPKMKNKPR SPVVELSKVP LVQRGSANGL; Positive Samples: HT-29, Mouse spleen, Mouse brain; Cellular Location: Cell membrane, Cytoplasm ADRBK1 (GRK2) is a serine/threonine kinase
- Many of the G protein-coupled receptors are known to be phosphorylated by G protein-dependent receptor kinases (GRKs)
- G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptors(GPCRs)
- GRK2 (83 kDa), one of six members of this family that have been identified, is ubiquitously expressed in mammals
- After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs (e.g., a2-adrenergic receptor) are phosphorylated by GRKs
- Internalization of the GPCRs, regulated by beta-arrestin-1, leads to activation of the Ras - Raf - ERK1&2 signaling pathway
- GRK2 activity is tightly controlled by different mechanisms including phosphorylation by kinases such as PKC, Src and ERK1&2, as well as interaction with various proteins
- ERK phosphorylates and thus inactivates GRK2 on serine 670 in a negative feedback mechanism.
Compare Similar Items
Show Difference
Antigen: GRK2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GRK2
Gene Alias: ADRBK1, Adrbk-1, adrenergic beta receptor kinase 1, adrenergic receptor kinase, beta 1, adrenergic, beta, receptor kinase 1, BARK, BARK1, Bark-1, beta ARK, Beta-adrenergic receptor kinase 1, beta-adrenergic receptor kinase 1 beta ARK1, beta-AR kinase-1, betaARK1, BETA-ARK1, beta-ARK-1, EC 2.7.1.126, G protein-coupled receptor kinase 2, G-protein coupled receptor kinase 2, G-protein-coupled receptor kinase 2, grk 2, Grk2, GRK-2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 110355, 156, 25238
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.12 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P25098, P26817, Q99MK8
Gene Symbols: GRK2
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 440-689 of human GRK2 (NP_0016102)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
GRK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GRK2
Gene Alias:
ADRBK1, Adrbk-1, adrenergic beta receptor kinase 1, adrenergic receptor kinase, beta 1, adrenergic, beta, receptor kinase 1, BARK, BARK1, Bark-1, beta ARK, Beta-adrenergic receptor kinase 1, beta-adrenergic receptor kinase 1 beta ARK1, beta-AR kinase-1, betaARK1, BETA-ARK1, beta-ARK-1, EC 2.7.1.126, G protein-coupled receptor kinase 2, G-protein coupled receptor kinase 2, G-protein-coupled receptor kinase 2, grk 2, Grk2, GRK-2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
110355, 156, 25238
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.12 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P25098, P26817, Q99MK8
Gene Symbols:
GRK2
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 440-689 of human GRK2 (NP_0016102)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CPSF4L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Cpsf4l
Gene Alias: 0610010C04Rik, 1500000C01Rik, cleavage and polyadenylation specific factor 4 like, cleavage and polyadenylation specific factor 4-like, Cpsf4l, D11Ertd636e, putative cleavage and polyadenylation specificity factor subunit 4-like protein, RGD1306397
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 52670
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.63 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: __
Gene Symbols: Cpsf4l
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-228 of mouse Cpsf4l (NP_0809582)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
CPSF4L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Cpsf4l
Gene Alias:
0610010C04Rik, 1500000C01Rik, cleavage and polyadenylation specific factor 4 like, cleavage and polyadenylation specific factor 4-like, Cpsf4l, D11Ertd636e, putative cleavage and polyadenylation specificity factor subunit 4-like protein, RGD1306397
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
52670
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.63 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
__
Gene Symbols:
Cpsf4l
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-228 of mouse Cpsf4l (NP_0809582)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: PCM1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PCM1
Gene Alias: 2600002H09Rik, 9430077F19Rik, C030044G17Rik, hPCM-1, mPCM-1, Pcm1, PCM-1, pericentriolar material 1, pericentriolar material 1 protein, pericentriolar material 1, PCM1, pericentriolar material gene 1, PTC4, RET/PCM-1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5108
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 0.57 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: Q15154
Gene Symbols: PCM1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_0061884)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
PCM1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PCM1
Gene Alias:
2600002H09Rik, 9430077F19Rik, C030044G17Rik, hPCM-1, mPCM-1, Pcm1, PCM-1, pericentriolar material 1, pericentriolar material 1 protein, pericentriolar material 1, PCM1, pericentriolar material gene 1, PTC4, RET/PCM-1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5108
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.57 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
Q15154
Gene Symbols:
PCM1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_0061884)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: MBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MBP
Gene Alias: 20 kDa microtubule-stabilizing protein, C76307, golli mbp, Golli-mbp, Golli-MBP, myelin basic protein, Golli-Mbp, myelin basic protein, myelin basic protein S, Hmbpr, MBP, MBP S, Mbps, MGC99675, microtubule-stabilizing protein, mLd, MOBP, Myelin A1 protein, myelin basic protein, myelin basic protein Golli-mbp, myelin basic protein S, myelin deficient, myelin membrane encephalitogenic protein, Myelin P1 protein, myelin-associated oligodendrocyte basic protein, R75289, shi, shiverer, Unknown (protein for IMAGE:7984318), unnamed protein product
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17196, 24547, 4155
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 6.99 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P02686, P02688, P04370
Gene Symbols: MBP
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-165 of human Myelin Basic Protein (NP_0010202721)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MBP
Gene Alias:
20 kDa microtubule-stabilizing protein, C76307, golli mbp, Golli-mbp, Golli-MBP, myelin basic protein, Golli-Mbp, myelin basic protein, myelin basic protein S, Hmbpr, MBP, MBP S, Mbps, MGC99675, microtubule-stabilizing protein, mLd, MOBP, Myelin A1 protein, myelin basic protein, myelin basic protein Golli-mbp, myelin basic protein S, myelin deficient, myelin membrane encephalitogenic protein, Myelin P1 protein, myelin-associated oligodendrocyte basic protein, R75289, shi, shiverer, Unknown (protein for IMAGE:7984318), unnamed protein product
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17196, 24547, 4155
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
6.99 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P02686, P02688, P04370
Gene Symbols:
MBP
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-165 of human Myelin Basic Protein (NP_0010202721)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG