PIPA596088
Presenilin 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596088-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA596088 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Presenilin 1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PSEN1
Gene Alias
AD3, Ad3h, Alzheimer Disease 3, FAD, Minilin, presenilin 1, presenilin 1 (Alzheimer disease 3), presenilin1, presenilin-1, Presenilin-1 CTF subunit, Presenilin-1 CTF12, Presenilin-1 NTF subunit, Protein S182, PS1, PS-1, PS1-CTF12, PSEN1, Psnl1, S182, S182 protein, Senilin 1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19164, 29192, 5663
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.47 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P49768, P49769, P97887
Gene Symbols
PSEN1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 290-380 of human Presenilin 1 (NP_0000121)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: STMVWLVNMA EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG PHRSTPESRA AVQELSSSIL AGEDPEERGV K Positive Samples: human kidney; Cellular Location: Cell membrane, Cell surface, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease
- In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer
- This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease
- Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site)
- It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease
- Multiple isoforms of presenilin1 are known to exist.
Compare Similar Items
Show Difference
Antigen: Presenilin 1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PSEN1
Gene Alias: AD3, Ad3h, Alzheimer Disease 3, FAD, Minilin, presenilin 1, presenilin 1 (Alzheimer disease 3), presenilin1, presenilin-1, Presenilin-1 CTF subunit, Presenilin-1 CTF12, Presenilin-1 NTF subunit, Protein S182, PS1, PS-1, PS1-CTF12, PSEN1, Psnl1, S182, S182 protein, Senilin 1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19164, 29192, 5663
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.47 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P49768, P49769, P97887
Gene Symbols: PSEN1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-380 of human Presenilin 1 (NP_0000121)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Presenilin 1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PSEN1
Gene Alias:
AD3, Ad3h, Alzheimer Disease 3, FAD, Minilin, presenilin 1, presenilin 1 (Alzheimer disease 3), presenilin1, presenilin-1, Presenilin-1 CTF subunit, Presenilin-1 CTF12, Presenilin-1 NTF subunit, Protein S182, PS1, PS-1, PS1-CTF12, PSEN1, Psnl1, S182, S182 protein, Senilin 1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19164, 29192, 5663
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.47 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P49768, P49769, P97887
Gene Symbols:
PSEN1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-380 of human Presenilin 1 (NP_0000121)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: p70 S6 Kinase
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RPS6KB1
Gene Alias: 10539, 2610318I15Rik, 4732464A07Rik, 70 kDa ribosomal protein S6 kinase 1, 7084, 70kDa, 7-10, AA959758, AI256796, AI314060, CG10539, CG10539-PA, CG10539-PB, Dmel\CG10539, Dmel_CG10539, Dp70[s6k], Dp70S6k, dps6k, dS6 kinase, dS6K, d-S6K, dS6K1, EC 2.7.11.1, fs(3)07084, hypothetical protein, kinase p70S6K, KS6B1, l(3)07084, p70 p70-S6K, p70 ribosomal S6 kinase, p70 ribosomal S6 kinase alpha, p70 S6 kinase, p70 S6 kinase 1, p70 S6 kinase alpha, p70 S6 kinase, alpha, p70 S6K, p70 S6KA, p70 S6K-alpha, p70(S6K)-alpha, p70/85s6k, p70/S6K, p70[S6 kinase], p70[S6k], p70[S6kinase], p70-alpha, p70S6 kinase, p70S6k, p70-S6K, p70-S6K 1, p70S6K kinase, p70s6k protein kinase homolog, P70S6K1, p70S6K-alpha, p80-S6K 1, p85 p85S6K, Pk?6, Pk64F, protein kinase-like 64F, PS6K, p-S6K, ribosomal protein S6 kinase, ribosomal protein S6 kinase B1, ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase I, ribosomal protein S6 kinase polypeptide 1, ribosomal protein S6 kinase, 70kD, polypeptide 1, ribosomal protein S6 kinase, 70kDa, polypeptide 1, ribosomal protein S6 kinase, polypeptide 1, ribosomal S6 protein kinase, Rps6kb1, RPS6-p70-protein kinase, S6 K, S6 kinase, s6k, S6K kinase, S6K1, s6k11, S6K-beta-1, S6kinase, S6-kinase, S6k-PA, S6k-PB, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A, STK14A
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6198, 72508, 83840
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.56 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P23443, P67999, Q8BSK8
Gene Symbols: RPS6KB1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 421-520 of human p70 S6 Kinase 1 (NP_0031521)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
p70 S6 Kinase
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RPS6KB1
Gene Alias:
10539, 2610318I15Rik, 4732464A07Rik, 70 kDa ribosomal protein S6 kinase 1, 7084, 70kDa, 7-10, AA959758, AI256796, AI314060, CG10539, CG10539-PA, CG10539-PB, Dmel\CG10539, Dmel_CG10539, Dp70[s6k], Dp70S6k, dps6k, dS6 kinase, dS6K, d-S6K, dS6K1, EC 2.7.11.1, fs(3)07084, hypothetical protein, kinase p70S6K, KS6B1, l(3)07084, p70 p70-S6K, p70 ribosomal S6 kinase, p70 ribosomal S6 kinase alpha, p70 S6 kinase, p70 S6 kinase 1, p70 S6 kinase alpha, p70 S6 kinase, alpha, p70 S6K, p70 S6KA, p70 S6K-alpha, p70(S6K)-alpha, p70/85s6k, p70/S6K, p70[S6 kinase], p70[S6k], p70[S6kinase], p70-alpha, p70S6 kinase, p70S6k, p70-S6K, p70-S6K 1, p70S6K kinase, p70s6k protein kinase homolog, P70S6K1, p70S6K-alpha, p80-S6K 1, p85 p85S6K, Pk?6, Pk64F, protein kinase-like 64F, PS6K, p-S6K, ribosomal protein S6 kinase, ribosomal protein S6 kinase B1, ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase I, ribosomal protein S6 kinase polypeptide 1, ribosomal protein S6 kinase, 70kD, polypeptide 1, ribosomal protein S6 kinase, 70kDa, polypeptide 1, ribosomal protein S6 kinase, polypeptide 1, ribosomal S6 protein kinase, Rps6kb1, RPS6-p70-protein kinase, S6 K, S6 kinase, s6k, S6K kinase, S6K1, s6k11, S6K-beta-1, S6kinase, S6-kinase, S6k-PA, S6k-PB, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A, STK14A
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6198, 72508, 83840
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.56 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P23443, P67999, Q8BSK8
Gene Symbols:
RPS6KB1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 421-520 of human p70 S6 Kinase 1 (NP_0031521)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD62E (E-selectin)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SELE
Gene Alias: CD62 antigen-like family member E, CD62E, e selectin, Elam, ELAM1, ELAM-1, endothelial adhesion molecule 1, endothelial leukocyte adhesion molecule, endothelial leukocyte adhesion molecule 1, endothelial leukocyte adhesion molecule I, ESEL, E-selectin, LECAM2, leukocyte endothelial cell adhesion molecule 2, leukocyte-endothelial cell adhesion molecule 2, RP1-117P20.2, SELE, selectin E, selectin E (endothelial adhesion molecule 1), selectin, endothelial cell
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20339, 25544, 6401
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 2.01 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P16581, P98105, Q00690
Gene Symbols: SELE
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-230 of human SELE (NP_0004412)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CD62E (E-selectin)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SELE
Gene Alias:
CD62 antigen-like family member E, CD62E, e selectin, Elam, ELAM1, ELAM-1, endothelial adhesion molecule 1, endothelial leukocyte adhesion molecule, endothelial leukocyte adhesion molecule 1, endothelial leukocyte adhesion molecule I, ESEL, E-selectin, LECAM2, leukocyte endothelial cell adhesion molecule 2, leukocyte-endothelial cell adhesion molecule 2, RP1-117P20.2, SELE, selectin E, selectin E (endothelial adhesion molecule 1), selectin, endothelial cell
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20339, 25544, 6401
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
2.01 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P16581, P98105, Q00690
Gene Symbols:
SELE
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-230 of human SELE (NP_0004412)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Zap-70
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ZAP70
Gene Alias: 70 kDa zeta-associated protein, 70 kDa zeta-chain associated protein, ADMIO2, EC 2.7.10.2, FLJ17670, FLJ17679, I79_004087, IMD48, kinase ZAP70, mrtle, mur, Selective T cell defect, Srk, STCD, STD, syk-related protein tyrosine kinase, syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase ZAP-70;TZK, TZK, ZA70, Zap70, ZAP-70, Zeta chain associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta-chain (TCR) associated protein kinase, zeta-chain (TCR) associated protein kinase 70, zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22637, 301348, 7535
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1.63 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P43403, P43404
Gene Symbols: ZAP70
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ZAP70 (NP_0010702)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Zap-70
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ZAP70
Gene Alias:
70 kDa zeta-associated protein, 70 kDa zeta-chain associated protein, ADMIO2, EC 2.7.10.2, FLJ17670, FLJ17679, I79_004087, IMD48, kinase ZAP70, mrtle, mur, Selective T cell defect, Srk, STCD, STD, syk-related protein tyrosine kinase, syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase ZAP-70;TZK, TZK, ZA70, Zap70, ZAP-70, Zeta chain associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta-chain (TCR) associated protein kinase, zeta-chain (TCR) associated protein kinase 70, zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22637, 301348, 7535
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1.63 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P43403, P43404
Gene Symbols:
ZAP70
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ZAP70 (NP_0010702)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG