PIPA596378
SMAD4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596378-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA596378 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
SMAD4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SMAD4
Gene Alias
AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17128, 4089, 50554
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.54 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
O70437, P97471, Q13485
Gene Symbols
SMAD4
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 320-552 of human Smad4 (NP_0053501)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Immunogen sequence: PEYWCSIAYF EMDVQVGETF KVPSSCPIVT VDGYVDPSGG DRFCLGQLSN VHRTEAIERA RLHIGKGVQL ECKGEGDVWV RCLSDHAVFV QSYYLDREAG RAPGDAVHKI YPSAYIKVFD LRQCHRQMQQ QAATAQAAAA AQAAAVAGNI PGPGSVGGIA PAISLSAAAG IGVDDLRRLC ILRMSFVKGW GPDYPRQSIK ETPCWIEIHL HRALQLLDEV LHTMPIADPQ PLD Positive Samples: HeLa, SKOV3, A673, 293T, HepG2; Cellular Location: Cytoplasm, Nucleus Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans
- Smad4 is also known as Smad family member 4, Sma- and Mad-related protein 4 or Mothers against decapentaplegic (MAD) homolog 4
- Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively
- Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad)
- This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus
- Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway
- Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation
- Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
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Antigen: SMAD4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SMAD4
Gene Alias: AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17128, 4089, 50554
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.54 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: O70437, P97471, Q13485
Gene Symbols: SMAD4
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 320-552 of human Smad4 (NP_0053501)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SMAD4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SMAD4
Gene Alias:
AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17128, 4089, 50554
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.54 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O70437, P97471, Q13485
Gene Symbols:
SMAD4
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 320-552 of human Smad4 (NP_0053501)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: TWEAK
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tnfsf12
Gene Alias: APO3 ligand, APO3/DR3 ligand, APO3L, Dr3l, Dr3lg, LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 12, MGC129581, MGC20669, TNF superfamily member 12, TNF-related weak inducer of apoptosis, TNFSF12, TNLG4A, tumor necrosis factor (ligand) superfamily member 12, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand 4A, tumor necrosis factor ligand superfamily member 12, Tumor necrosis factor ligand superfamily member 12, membrane form, Tumor necrosis factor ligand superfamily member 12, secreted form, tumor necrosis factor superfamily member 12, TWEAK, UNQ181/PRO207, zgc:153941
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21944, 360548, 8742
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.8 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: O43508, O54907
Gene Symbols: Tnfsf12
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-123 of human TNFSF12 (NP_0038001)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
TWEAK
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tnfsf12
Gene Alias:
APO3 ligand, APO3/DR3 ligand, APO3L, Dr3l, Dr3lg, LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 12, MGC129581, MGC20669, TNF superfamily member 12, TNF-related weak inducer of apoptosis, TNFSF12, TNLG4A, tumor necrosis factor (ligand) superfamily member 12, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand 4A, tumor necrosis factor ligand superfamily member 12, Tumor necrosis factor ligand superfamily member 12, membrane form, Tumor necrosis factor ligand superfamily member 12, secreted form, tumor necrosis factor superfamily member 12, TWEAK, UNQ181/PRO207, zgc:153941
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21944, 360548, 8742
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.8 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
O43508, O54907
Gene Symbols:
Tnfsf12
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-123 of human TNFSF12 (NP_0038001)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD10
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Mme
Gene Alias: 6030454K05Rik, Atriopeptidase, C85356, CALLA, CD10, CMT2T, common acute lymphoblastic leukemia antigen, common acute lymphocytic leukemia antigen, Enkephalinase, EPN, membrane metallo endopeptidase, membrane metalloendopeptidase, membrane metallo-endopeptidase, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase), membrane metallo-endopeptidase variant 1, membrane metallo-endopeptidase variant 2, MME, NEP, neprilysin, neprilysin-390, neprilysin-411, neutral endopeptidase 24.11, SFE, Skin fibroblast elastase
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17380, 24590, 4311
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.89 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P07861, P08473, Q61391
Gene Symbols: Mme
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 52-352 of human CD10/MME (NP_0008932)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CD10
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Mme
Gene Alias:
6030454K05Rik, Atriopeptidase, C85356, CALLA, CD10, CMT2T, common acute lymphoblastic leukemia antigen, common acute lymphocytic leukemia antigen, Enkephalinase, EPN, membrane metallo endopeptidase, membrane metalloendopeptidase, membrane metallo-endopeptidase, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase), membrane metallo-endopeptidase variant 1, membrane metallo-endopeptidase variant 2, MME, NEP, neprilysin, neprilysin-390, neprilysin-411, neutral endopeptidase 24.11, SFE, Skin fibroblast elastase
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17380, 24590, 4311
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.89 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P07861, P08473, Q61391
Gene Symbols:
Mme
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 52-352 of human CD10/MME (NP_0008932)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD74
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CD74
Gene Alias: CD74, CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, Cd74 molecule, major histocompatibility complex, class II invariant chain, class II-associated invariant chain peptide, CLIP, DHLAG, dinucleotide microsatellite, gamma chain of class II antigens, H-2 class II histocompatibility antigen gamma chain, histocompatibility: class II antigens, gamma chain of, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-GAMMA, Ii, invariant polypeptide of major histocompatibility complex, class II antigen-associated, INVG34, MHC class II-associated invariant chain, MHC HLA-DR gamma chain, p33
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25599, 972
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.27 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P04233, P10247
Gene Symbols: CD74
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 73-232 of human CD74 (NP_0043461)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CD74
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CD74
Gene Alias:
CD74, CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, Cd74 molecule, major histocompatibility complex, class II invariant chain, class II-associated invariant chain peptide, CLIP, DHLAG, dinucleotide microsatellite, gamma chain of class II antigens, H-2 class II histocompatibility antigen gamma chain, histocompatibility: class II antigens, gamma chain of, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-GAMMA, Ii, invariant polypeptide of major histocompatibility complex, class II antigen-associated, INVG34, MHC class II-associated invariant chain, MHC HLA-DR gamma chain, p33
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25599, 972
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.27 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P04233, P10247
Gene Symbols:
CD74
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 73-232 of human CD74 (NP_0043461)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG