PIPA596894
PHD3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596894-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA596894 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
PHD3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
EGLN3
Gene Alias
2610021G09Rik, AI505553, AI648162, Egl nine homolog 3, egl nine homolog 3, mitochondrial, egl nine-like protein 3 isoform, egl-9 family hypoxia inducible factor 3, egl-9 family hypoxia-inducible factor 3, EGLN3, factor-responsive smooth muscle protein, FLJ21620, HIF prolyl hydroxylase 3, HIFP4H3, Hif-p4h-3, HIFPH3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, hypoxia-inducible factor prolyl hydroxylase 3, MGC125998, MGC125999, P4H3, Phd3, PHD-3, prolyl hydroxylase domain-containing protein 3, Sm20, SM-20
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
112399, 112407, 54702
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
2.44 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
Q62630, Q91UZ4, Q9H6Z9
Gene Symbols
EGLN3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PHD3 (NP_0713561)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MPLGHIMRLD LEKIALEYIV PCLHEVGFCY LDNFLGEVVG DCVLERVKQL HCTGALRDGQ LAGPRAGVSK RHLRGDQITW IGGNEEGCEA ISFLLSLIDR Positive Samples: Mouse liver; Cellular Location: Cytoplasm, Nucleus Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins
- Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A
- Also hydroxylates HIF2A
- Has a preference for the CODD site for both HIF1A and HIF2A
- Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site
- Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex
- Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes
- EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia
- Also hydroxylates PKM in hypoxia, limiting glycolysis
- Under normoxia, hydroxylates and regulates the stability of ADRB2
- Regulator of cardiomyocyte and neuronal apoptosis
- In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex
- In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity
- Also essential for hypoxic regulation of neutrophilic inflammation
- Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway
- Target proteins are preferentially recognized via a LXXLAP motif.
Compare Similar Items
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Antigen: PHD3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EGLN3
Gene Alias: 2610021G09Rik, AI505553, AI648162, Egl nine homolog 3, egl nine homolog 3, mitochondrial, egl nine-like protein 3 isoform, egl-9 family hypoxia inducible factor 3, egl-9 family hypoxia-inducible factor 3, EGLN3, factor-responsive smooth muscle protein, FLJ21620, HIF prolyl hydroxylase 3, HIFP4H3, Hif-p4h-3, HIFPH3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, hypoxia-inducible factor prolyl hydroxylase 3, MGC125998, MGC125999, P4H3, Phd3, PHD-3, prolyl hydroxylase domain-containing protein 3, Sm20, SM-20
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 112399, 112407, 54702
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 2.44 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: Q62630, Q91UZ4, Q9H6Z9
Gene Symbols: EGLN3
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PHD3 (NP_0713561)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PHD3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EGLN3
Gene Alias:
2610021G09Rik, AI505553, AI648162, Egl nine homolog 3, egl nine homolog 3, mitochondrial, egl nine-like protein 3 isoform, egl-9 family hypoxia inducible factor 3, egl-9 family hypoxia-inducible factor 3, EGLN3, factor-responsive smooth muscle protein, FLJ21620, HIF prolyl hydroxylase 3, HIFP4H3, Hif-p4h-3, HIFPH3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, hypoxia-inducible factor prolyl hydroxylase 3, MGC125998, MGC125999, P4H3, Phd3, PHD-3, prolyl hydroxylase domain-containing protein 3, Sm20, SM-20
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
112399, 112407, 54702
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
2.44 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
Q62630, Q91UZ4, Q9H6Z9
Gene Symbols:
EGLN3
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PHD3 (NP_0713561)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: EFHC1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EFHC1
Gene Alias: 1700029F22Rik, dJ304B14.2, EF-hand domain (C-terminal) containing 1, EF-hand domain containing 1, EF-hand domain-containing protein 1, EFHC1, EJM1, mRib72-1, myoclonin1, myoclonin-1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 114327, 301295, 71877
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.89 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: Q5JVL4, Q9D9T8
Gene Symbols: EFHC1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 391-640 of human EFHC1 (NP_0605702)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
EFHC1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EFHC1
Gene Alias:
1700029F22Rik, dJ304B14.2, EF-hand domain (C-terminal) containing 1, EF-hand domain containing 1, EF-hand domain-containing protein 1, EFHC1, EJM1, mRib72-1, myoclonin1, myoclonin-1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
114327, 301295, 71877
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.89 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
Q5JVL4, Q9D9T8
Gene Symbols:
EFHC1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 391-640 of human EFHC1 (NP_0605702)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SOCS4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SOCS4
Gene Alias: 3110032M18Rik, A730004F22Rik, AI427843, AU015727, AU015859, SH2 domain containing SOCS box protein, SOCS4, SOCS-4, SOCS7, SOCS-7, suppressor of cytokine signaling 4, Suppressor of cytokine signaling 7, suppressor of cytokine signalling 4
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 122809, 67296
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 2.16 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: Q8WXH5, Q91ZA6
Gene Symbols: SOCS4
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_5431431)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
SOCS4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SOCS4
Gene Alias:
3110032M18Rik, A730004F22Rik, AI427843, AU015727, AU015859, SH2 domain containing SOCS box protein, SOCS4, SOCS-4, SOCS7, SOCS-7, suppressor of cytokine signaling 4, Suppressor of cytokine signaling 7, suppressor of cytokine signalling 4
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
122809, 67296
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
2.16 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
Q8WXH5, Q91ZA6
Gene Symbols:
SOCS4
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_5431431)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: SNX32
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SNX32
Gene Alias: B930037P14Rik, RGD1560591, SNX32, Snx6b, sortin nexin-6B, sorting nexin 32, sorting nexin 6B, sorting nexin-32, Sorting nexin-6B
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 225861, 254122, 361708
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1.81 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: Q80ZJ7, Q86XE0
Gene Symbols: SNX32
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 218-285 of human SNX32 (NP_6899732)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SNX32
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SNX32
Gene Alias:
B930037P14Rik, RGD1560591, SNX32, Snx6b, sortin nexin-6B, sorting nexin 32, sorting nexin 6B, sorting nexin-32, Sorting nexin-6B
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
225861, 254122, 361708
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1.81 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
Q80ZJ7, Q86XE0
Gene Symbols:
SNX32
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 218-285 of human SNX32 (NP_6899732)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG