PIPA599967
VPRBP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA599967-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA599967 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
VPRBP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DCAF1
Gene Alias
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
315987, 321006, 9730
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q80TR8, Q9Y4B6
Gene Symbols
DCAF1
Immunogen
A synthesized peptide derived from human DCAF1(Accession Q9Y4B6), corresponding to amino acid residues D30-K80.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Antibody detects endogenous levels of total VPRBP
- Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification
- Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2
- Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex
- The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination
- Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition
- Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription
- H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors
- Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2
- In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase
- The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT
- In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
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Antigen: VPRBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DCAF1
Gene Alias: AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 315987, 321006, 9730
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q80TR8, Q9Y4B6
Gene Symbols: DCAF1
Immunogen: A synthesized peptide derived from human DCAF1(Accession Q9Y4B6), corresponding to amino acid residues D30-K80.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
VPRBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DCAF1
Gene Alias:
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
315987, 321006, 9730
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q80TR8, Q9Y4B6
Gene Symbols:
DCAF1
Immunogen:
A synthesized peptide derived from human DCAF1(Accession Q9Y4B6), corresponding to amino acid residues D30-K80.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SMCR7L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MIEF1
Gene Alias: A230016E22; AI452372; dJ1104E15.3; HSU79252; MID51; Mief1; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smcr7l; SMCR7-like protein; smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; Smith-Magenis syndrome chromosome region, candidate 7-like
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 239555, 315141, 54471
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q5XIS8, Q8BGV8, Q9NQG6
Gene Symbols: MIEF1
Immunogen: A synthesized peptide derived from human MIEF1(Accession Q9NQG6), corresponding to amino acid residues V162-Q212.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SMCR7L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MIEF1
Gene Alias:
A230016E22; AI452372; dJ1104E15.3; HSU79252; MID51; Mief1; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smcr7l; SMCR7-like protein; smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; Smith-Magenis syndrome chromosome region, candidate 7-like
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
239555, 315141, 54471
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q5XIS8, Q8BGV8, Q9NQG6
Gene Symbols:
MIEF1
Immunogen:
A synthesized peptide derived from human MIEF1(Accession Q9NQG6), corresponding to amino acid residues V162-Q212.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: TPI1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tpi1
Gene Alias: AI255506; epididymis secretory protein Li 49; HEL-S-49; Methylglyoxal synthase; MGC88108; TIM; Tpi; TPI1; Tpi-1; TPID; triosephosphate isomerase; triose-phosphate isomerase; triosephosphate isomerase 1; triose-phosphate isomerase TPI1; unnamed protein product; YD9609.05C; YDR050C
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21991, 24849, 7167
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P17751, P48500, P60174
Gene Symbols: Tpi1
Immunogen: A synthesized peptide derived from human TPI1(Accession P60174), corresponding to amino acid residues T254-Q286.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
TPI1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tpi1
Gene Alias:
AI255506; epididymis secretory protein Li 49; HEL-S-49; Methylglyoxal synthase; MGC88108; TIM; Tpi; TPI1; Tpi-1; TPID; triosephosphate isomerase; triose-phosphate isomerase; triosephosphate isomerase 1; triose-phosphate isomerase TPI1; unnamed protein product; YD9609.05C; YDR050C
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21991, 24849, 7167
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P17751, P48500, P60174
Gene Symbols:
Tpi1
Immunogen:
A synthesized peptide derived from human TPI1(Accession P60174), corresponding to amino acid residues T254-Q286.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: YME1L1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: YME1L1
Gene Alias: ATP-dependent metalloprotease FtsH1; ATP-dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease YME1L1; ATP-dependent metalloprotease YME1L1-like protein; ATP-dependent zinc metalloprotease YME1L1; ATP-dependent zinc metalloprotease YME1l1-like protein; FTSH; FTSH1; MEG4; meg-4; PAMP; Presenilin-associated metalloprotease; UNQ1868/PRO4304; YME1 like 1 ATPase; YME1L; YME1L1; YME1-like 1 (S. cerevisiae); YME1-like 1 ATPase; YME1-like protein 1
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10730, 114217, 27377
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O88967, Q925S8, Q96TA2
Gene Symbols: YME1L1
Immunogen: A synthesized peptide derived from human YME1L1(Accession Q96TA2), corresponding to amino acid residues L648-L698.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
YME1L1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
YME1L1
Gene Alias:
ATP-dependent metalloprotease FtsH1; ATP-dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease YME1L1; ATP-dependent metalloprotease YME1L1-like protein; ATP-dependent zinc metalloprotease YME1L1; ATP-dependent zinc metalloprotease YME1l1-like protein; FTSH; FTSH1; MEG4; meg-4; PAMP; Presenilin-associated metalloprotease; UNQ1868/PRO4304; YME1 like 1 ATPase; YME1L; YME1L1; YME1-like 1 (S. cerevisiae); YME1-like 1 ATPase; YME1-like protein 1
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10730, 114217, 27377
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O88967, Q925S8, Q96TA2
Gene Symbols:
YME1L1
Immunogen:
A synthesized peptide derived from human YME1L1(Accession Q96TA2), corresponding to amino acid residues L648-L698.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG