IgA (α-Heavy Chain) Ab-2 Rabbit Polyclonal Antibody, Epredia™

Description

• The most common feature of plasmacytomas, and certain non-Hodgkin's lymphomas is the restricted expression of a single heavy chain class
• Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant
• Host Species: Rabbit Isotype: IgG Species Reactivity: Human
• Others not known
• Epitope: Not determined Immunogen: IgA isolated from a pool of normal human sera Molecular Weight: 50kDa Positive Control: Tonsil Cellular Localization: Cytoplasmic Ab-2 recognizes a protein of 50kDa, identified as alpha heavy chain of human immunoglobulins
• It reacts with both IgA1 and IgA2 isotypes
• Ab-2 does not cross-react with γ (IgG), μ (IgM), ε (IgE), or δ (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes
• Ab-2 is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas
• Recommended for: Immunohistochemistry (Formalin/paraffin)