Factor VIII Related Antigen/von Willebrand Factor Ab-1 Rabbit Polyclonal Antibody, Epredia™

Description

• Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein
• It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin
• von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules
• It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII
• von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms
• As not all endothelial cells synthesize/store this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant
• Staining for factor VIII related antigen has also been used to measure angiogenesis an indicator of tumor recurrence
• Host Species: Rabbit Isotype: IgG Species Reactivity: Human
• Others not known
• Epitope: Not determined Immunogen: Purified factor VIII related antigen/von Willebrand factor Molecular Weight: 270 kDa Positive Control: Tonsil Cellular Localization: Cytoplasmic Recommended for: Immunohistochemistry (Formalin/paraffin) Immunofluorescence