CD117/c-Kit/SCF-Receptor Rabbit Polyclonal Antibody, Epredia™

Description

• Recognizes a protein of 145kDa, which is identified as CD117/p145kit
• This rabbit polyclonal antibody does not interfere with the binding of SCF to c-kit
• It precipitates both the unoccupied as well as the occupied form of c-kit
• The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase (Type III) stimulates a variety of biochemical responses that culminate in cellular proliferation, migration, or survival
• C-kit plays an important role in hematopoiesis, melanogenesis, and gametogenesis
• This antibody is excellent for staining of formalin-fixed, paraffin-embedded tissues
• Host Species: Rabbit Isotype: IgG Species Reactivity: Human and Dog
• Others not tested Epitope: Cytoplasmic domain Immunogen: A synthetic peptide from the cytoplasmic domain of human CD117/c-kit protein Molecular Weight: 145 kDa Positive Control: Stromal tumor, skin or tonsil Cellular Localization: Membrane Recommended for: Immunohistochemistry (Formalin/paraffin)