Laminin B2/γ1 Ab-1 Rat Monoclonal Antibody, Epredia™

Description

• Laminins are large heterotrimeric, noncollagenous glycoproteins composed of α, β, and γ chains
• They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM
• Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms
• Host Species: Rat Clone: A5 Isotype: IgG2a/κ Species Reactivity: Human and Mouse
• Others not known
• Epitope: Not determined Immunogen: Murine EHS laminin preparation Molecular Weight: ∽210kDa Positive Control: LS174T cells, Normal colon or colon CA Cellular Localization: Basement membrane Specificity of Ab-1 was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs
• Ab-1 stains uniformly all human and murine basement membranes
• Recommended for: Immunohistochemistry (Acetone-fixed frozen and acid-alcohol-fixed, paraffin-embedded) Immunofluorescence Immunoprecipitation (Native and denatured) Note: USA: RUO; Int'l: RUO