MilliporeSigma™ anti-GNA13 Clone: 6F6-B5,

Description

• Specifically detects GNA13 Clone: 6F6-B5 in Human samples, and it is validated for ELISA, Immuno Blotting Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors
• Each G protein contains an α-, β- and γ-subunit and is bound to GDP in the 'off' state
• Ligand binding to a 7-TM receptor causes a conformational change in the receptor, which detaches the G protein
• This reaction switches the G protein to an 'on' state, allowing GTP to displace GDP, thus G α can activate second messenger signaling cascades
• There are several types of G α proteins; G αs and G αi bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively
• G αq/11 stimulates PLCβ which catalyzes the hydroylsis of PIP2 to the second messengers IP3 and DAG
• Gv12/13 are involved in Rho family GTPase signaling
• In addition, some G βγ subunits have active functions; G βv coupled to H1 receptors can activate PLA2 and G βγ coupled to M1 receptors can activate KIR channels
• Rapid termination of the cellular response is required once the concentration of the stimulating ligand decreases
• GTP bound to G α is hydrolyzed rapidly to GDP, G α is converted to its inactive form and re-associates with the β- and γ-subunits returning to the 'off' state.