Description

• A cell-permeable, orally bioavailable, nontoxic, nonsteroidal naphthylmethylimidazole compound that as a potent, selective and reversible inhibitor of 17,20-lyase (IC 50 = 140 nM, 27 nM, and 1.2μM in human, monkey, and rat, respectively) and reduces the weight of androgen-dependent organs
• At higher concentrations, affects 17α-hydroxylase (IC 50 = 760, 38 and > 10,000nM in human, monkey and rat, respectively) activity with minimal effect on 11β-hydroxylase
• Suppresses testosterone (IC 50 = 640nM) and androstenedione (IC 50 = 210nM) production without affecting the synthesis of corticosterone or aldosterone in rats (up to 30μM)
• Displays desirable pharmacokinetic properties (t 1/2 - 3.8 h; T max = 1.7 h; AUC = 0.727 mg h/ml following an oral dose of 1mg/kg in monkey)
• Please note that the molecular weight for this compound is batch-specific due to variable water content.