69587

2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate

suitable for fluorescence, BioReagent, ≥96.5% (HPLC)

Manufacturer: Sigma Aldrich

CAS Number: 76204-02-9

Synonym(S): 4-MUNANA, 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid sodium salt hydrate, 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid sodium salt hydrate

Select a Size

Pack Size SKU Availability Price
5 MG 69587-5-MG In Stock ₹ 32,215.20
25 MG 69587-25-MG In Stock ₹ 1,37,932.15

69587 - 5 MG

₹ 32,215.20

In Stock

Quantity

1

Base Price: ₹ 32,215.20

GST (18%): ₹ 5,798.736

Total Price: ₹ 38,013.936

product line

BioReagent

Assay

≥96.5% (HPLC)

form

powder

impurities

≤0.5% free 4-methylumbelliferone≤10% water

solubility

H2O: 50 mg/mL, clear, very slightly yellow

fluorescence

λex 315 nm; λem 374 nm (pH.7.0)λex 365 nm; λem 445 nm (after cleavage by neuraminidase)

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]

InChI

1S/C21H25NO11.Na.H2O/c1-9-5-16(27)31-15-6-11(3-4-12(9)15)32-21(20(29)30)7-13(25)17(22-10(2)24)19(33-21)18(28)14(26)8-23;;/h3-6,13-14,17-19,23,25-26,28H,7-8H2,1-2H3,(H,22,24)(H,29,30);;1H2/q;+1;/p-1/t13-,14?,17+,18?,19+,21+;;/m0../s1

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Description

  • General description: 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid or 4-MUNANA is a synthetic fluorometric substrate[1] that mimics the naturally occurring neuraminidase enzyme substrate.[2] The enzyme-substrate hydrolysis results in the product 4-methylumbelliferone (4-MU), measured fluorometrically.[2]
  • Application: 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid or 4-MUNANA is used as a substrate for the development of a microplate-based assay for neuraminidase inhibitors.[3] The fluorogenic substrate 2ʹ-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid (4-MUNANA) is used to study the molecular mechanisms of aspirin and celecoxib targeting mammalian neuraminidase-1.[4]
  • Biochem/physiol Actions: Substrate for fluorometric assay of neuraminidase. Used for fluorescent staining of sialidases in PAGE.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Show Difference

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Sigma Aldrich

69587

suitable for fluorescence, BioReage...


product line:
BioReagent

Assay:
≥96.5% (HPLC)

form:
powder

impurities:
≤0.5% free 4-methylumbelliferone≤10% water

solubility:
H2O: 50 mg/mL, clear, very slightly yellow

fluorescence:
λex 315 nm; λem 374 nm (pH.7.0)λex 365 nm; λem 445 nm (after cleavage by neuraminidase)

suitability:
suitable for fluorescence

storage temp.:
−20°C

SMILES string:
O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]

InChI:
1S/C21H25NO11.Na.H2O/c1-9-5-16(27)31-15-6-11(3-4-12(9)15)32-21(20(29)30)7-13(25)17(22-10(2)24)19(33-21)18(28)14(26)8-23;;/h3-6,13-14,17-19,23,25-26,28H,7-8H2,1-2H3,(H,22,24)(H,29,30);;1H2/q;+1;/p-1/t13-,14?,17+,18?,19+,21+;;/m0../s1

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Sigma Aldrich

695874

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__

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__

form:
solid

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__

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__

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__

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__

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__

SMILES string:
CN(C)c1ccccc1-c2ccccc2P(C(C)(C)C)C(C)(C)C

InChI:
1S/C22H32NP/c1-21(2,3)24(22(4,5)6)20-16-12-10-14-18(20)17-13-9-11-15-19(17)23(7)8/h9-16H,1-8H3

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__

SMILES string:
CN(C)c1ccccc1-c2ccccc2P(c3ccccc3)c4ccccc4

InChI:
1S/C26H24NP/c1-27(2)25-19-11-9-17-23(25)24-18-10-12-20-26(24)28(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h3-20H,1-2H3

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C=CC=C

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1S/C4H6/c1-3-4-2/h3-4H,1-2H2