SML2923
ARV-771
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1949837-12-0
Synonym(S): JQ1-VHL
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML2923-5-MG | In Stock | ₹ 15,772.03 |
| 25 MG | SML2923-25-MG | In Stock | ₹ 50,769.25 |
SML2923 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 15,772.03
GST (18%): ₹ 2,838.965
Total Price: ₹ 18,610.995
ligand
VH032
Quality Level
100
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-100972 1mg Medchemexpress, ARV-771 CAS:1949837-12-0 Purity:>98% | Medchemexpress LLC | ₹ 6,288.66 | |
 | ARV-771 | ChemScene | ₹ 46,630.20 - ₹ 60,833.16 | |
 | 1949837-12-0 | Arv-771 | A2B Chem | ₹ 4,449.12 - ₹ 1,38,607.20 |
Related Products
Description
- Biochem/physiol Actions: ARV-771 is a bromodomain and extraterminal (BET) proteins degrader with a HIF-1?-derived von Hippel–Landau (VHL) E3 ligase-binding hydroxyproline and a BET-binding triazolo-diazepine acetamide. ARV-771 induces BET proteins degradation in castrate-resistent prostate cancer (CRPC) cultures (BRD2/3/4 DC50 <5 nM; 22Rv1, VCaP & LnCaP95) and reduces downstream c-Myc transcription with 10-500-fold higher potency than JQ-1, OTX015, and dBET1. ARV-771, but not JQ-1 or OTX015, effectively downregulates CRPC androgen receptor (30-300 nM) and causes CRPC tumor growth retardation/regression in mice in vivo (30 mg/kg s.c.; 22Rv1 and VCaP).
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: VH032
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: 2-8°C
ligand:
VH032
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
ligand: E7820
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
color: white to beige
solubility: DMSO: 2 mg/mL, clear
storage temp.: 2-8°C
ligand:
E7820
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
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