Nutlin-3a
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 675576-98-4
Synonym(S): (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one, (-)-Nutlin-3, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone, Nutlin 3a
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML0580-5-MG | In Stock | ₹ 34,754.10 |
| 25 MG | SML0580-25-MG | In Stock | ₹ 95,915.10 |
SML0580 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 34,754.10
GST (18%): ₹ 6,255.738
Total Price: ₹ 41,009.838
ligand
nutlin-3a
Quality Level
100
Assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -130 to -154° (c=0.5, CDCl3)
reaction suitability
reagent type: ligand
color
white to beige
solubility
DMSO: 5 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Other Options
Related Products
Description
- Application: Nutlin-3a has been used as a tumor suppressor p53(TP53) stabilizer and as an inhibitor of the mouse double minute 2 homolog (MDM2)–p53 interaction.[1][2][3][4]
- Biochem/physiol Actions: Nutlin-3a [(-)-Nutlin] is a more potent diastereoisomer of racemic MDM2 antagonist Nutlin-3. It was called enantiomer-a since it elutes as the first peak from chiral purification of racemic nutlin-3. Nutlin-3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Nutlin-3a is 150 times more potent than Nutlin-3b.
- Features and Benefits: This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: nutlin-3a
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
optical activity: [α]/D -130 to -154° (c=0.5, CDCl3)
reaction suitability: reagent type: ligand
color: white to beige
solubility: DMSO: 5 mg/mL, clear
shipped in: wet ice
storage temp.: −20°C
ligand: __
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
optical activity: __
reaction suitability: __
color: white to beige
solubility: DMSO: 5 mg/mL, clear (warmed)
shipped in: __
storage temp.: 2-8°C
ligand: __
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
optical activity: __
reaction suitability: __
color: white to beige
solubility: DMSO: 20 mg/mL, clear
shipped in: __
storage temp.: 2-8°C
