M5525

4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

≥98%, powder

Manufacturer: Sigma Aldrich

CAS Number: 64987-85-5

Synonym(S): N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC

Select a Size

Pack Size SKU Availability Price
5 MG M5525-5-MG In Stock ₹ 3,583.08
25 MG M5525-25-MG In Stock ₹ 15,241.60
100 MG M5525-100-MG In Stock ₹ 43,440.73

M5525 - 5 MG

₹ 3,583.08

In Stock

Quantity

1

Base Price: ₹ 3,583.08

GST (18%): ₹ 644.954

Total Price: ₹ 4,228.034

Quality Level

200

Assay

≥98%

form

powder

reaction suitability

reagent type: linker

mp

180-182 °C (lit.)

solubility

chloroform: 50 mg/mLDMF: soluble

functional group

NHS ester

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C(ON1C(CCC1=O)=O)C2CCC(CN3C(C=CC3=O)=O)CC2

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Description

  • General description: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity.[1] It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
  • Application: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.[2]

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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powder

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180-182 °C (lit.)

solubility:
chloroform: 50 mg/mLDMF: soluble

functional group:
NHS ester

shipped in:
wet ice

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−20°C

SMILES string:
O=C(ON1C(CCC1=O)=O)C2CCC(CN3C(C=CC3=O)=O)CC2

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