Description

• GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels
• GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells
• GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response
• GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells
• GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice
• GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.