50-135-0RD

Tocris Bioscience™ AC 710

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-135-0RD-Each-of-1 In Stock ₹ 1,39,548.36

50-135-0RD - Each of 1

₹ 1,39,548.36

In Stock

Quantity

1

Base Price: ₹ 1,39,548.36

GST (18%): ₹ 25,118.705

Total Price: ₹ 1,64,667.065

Purity

>99%

Molecular Weight (g/mol)

562.7

Quantity

50 mg

Description

AC 710

Product Type

AC 710

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Description

  • Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα)
  • Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450
  • Causes tumor regression of leukemia cell xenografts in mice
  • Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis
  • Orally active.

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