5545516
Tocris Bioscience™ AC 710
Potent and selective PDGFR family inhibitor
Manufacturer: Fischer Scientific
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Purity
>99%
Description
AC 710
Molecular Weight (g/mol)
562.7
Product Type
AC 710
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Description
- Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα)
- Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450
- Causes tumor regression of leukemia cell xenografts in mice
- Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis
- Orally active.
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Purity: >99%
Description: AC 710
Molecular Weight (g/mol): 562.7
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Molecular Weight (g/mol):
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Molecular Weight (g/mol): 609.83
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