PV4422
Invitrogen™ Fluorescein-PGC1a Coactivator Peptide, 100 μM
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PV4422-Each-of-1 | In Stock | ₹ 91,136.00 |
PV4422 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 91,136.00
GST (18%): ₹ 16,404.48
Total Price: ₹ 1,07,540.48
Content And Storage
Store in freezer (-5 to -30°C).
Label Type
Classic Dyes
Quantity
1 mL
Shipping Condition
Dry Ice
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Description
- Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes
- TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide
- In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein
- An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide
- The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio.
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Content And Storage: Store in freezer (-5 to -30°C).
Label Type: Classic Dyes
Quantity: 1 mL
Shipping Condition: Dry Ice
Content And Storage:
Store in freezer (-5 to -30°C).
Label Type:
Classic Dyes
Quantity:
1 mL
Shipping Condition:
Dry Ice
Content And Storage: LanthaScreen™ DUB substate in HEPES buffered saline. Store at -80°C.
Label Type: __
Quantity: 100 μg
Shipping Condition: Dry Ice
Content And Storage:
LanthaScreen™ DUB substate in HEPES buffered saline. Store at -80°C.
Label Type:
__
Quantity:
100 μg
Shipping Condition:
Dry Ice
Content And Storage: GFP-ATF2 protein substrate in 10 mM Tris, pH 7.5, 150 mM NaCl, 10% glycerol, 1mM DTT. Store at -80°C.
Label Type: __
Quantity: 20 nmol
Shipping Condition: Dry Ice
Content And Storage:
GFP-ATF2 protein substrate in 10 mM Tris, pH 7.5, 150 mM NaCl, 10% glycerol, 1mM DTT. Store at -80°C.
Label Type:
__
Quantity:
20 nmol
Shipping Condition:
Dry Ice
Content And Storage: GFP-c-Jun protein substrate in 10 mM Tris, pH 7.5, 150 mM NaCl, 10% glycerol, 1 mM DTT. Store (at -80°C.)
Label Type: __
Quantity: 20 nmol
Shipping Condition: Dry Ice
Content And Storage:
GFP-c-Jun protein substrate in 10 mM Tris, pH 7.5, 150 mM NaCl, 10% glycerol, 1 mM DTT. Store (at -80°C.)
Label Type:
__
Quantity:
20 nmol
Shipping Condition:
Dry Ice