PV4616
Thermo Scientific™ FL-AR N-TERM Peptide
Manufacturer: Thermo Scientific™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PV4616-Each-of-1 | In Stock | ₹ 15,999.72 |
PV4616 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,999.72
GST (18%): ₹ 2,879.95
Total Price: ₹ 18,879.67
Content And Storage
100 μM Fluorescein-AR N-term Peptide in 99.9% DMSO, 0.1% formic acid.Store at -20°C and protect from light.
Label Type
Classic Dyes
Quantity
100 μL
Shipping Condition
Dry Ice
Related Products
Description
- LanthaScreen™ fluorescent nuclear receptor coregulator peptides contain known interaction motifs and are labeled with fluorescein
- These peptides are matched and validated to complement the LanthaScreen™ TR-FRET Nuclear Receptor Coregulator Assays
- Assays developed using these reagents enable primary or secondary screening of nuclear receptor agonists and/or antagonists
- How they work Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes
- TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide
- In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein
- An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide (Figure 1)
- The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio (Figure 2)
- Contents and Storage: LanthaScreen™ fluorescent nuclear receptor coregulator peptides are supplied as 100 μM solutions in peptide-appropriate buffers
- Store peptides at -20°C.
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Content And Storage: 100 μM Fluorescein-AR N-term Peptide in 99.9% DMSO, 0.1% formic acid.Store at -20°C and protect from light.
Label Type: Classic Dyes
Quantity: 100 μL
Shipping Condition: Dry Ice
Content And Storage:
100 μM Fluorescein-AR N-term Peptide in 99.9% DMSO, 0.1% formic acid.Store at -20°C and protect from light.
Label Type:
Classic Dyes
Quantity:
100 μL
Shipping Condition:
Dry Ice
Content And Storage: Store in freezer (-5 to -30°C).
Label Type: Classic Dyes
Quantity: 100 μL
Shipping Condition: Dry Ice
Content And Storage:
Store in freezer (-5 to -30°C).
Label Type:
Classic Dyes
Quantity:
100 μL
Shipping Condition:
Dry Ice
Content And Storage: 100 μM Fluorescein-SMRT ID1 Peptide in 99.9% DMSO, 0.1% TFA. Store at -20°C and protect from light.
Label Type: Classic Dyes
Quantity: 100 μL
Shipping Condition: Dry Ice
Content And Storage:
100 μM Fluorescein-SMRT ID1 Peptide in 99.9% DMSO, 0.1% TFA. Store at -20°C and protect from light.
Label Type:
Classic Dyes
Quantity:
100 μL
Shipping Condition:
Dry Ice
Content And Storage: TR-FRET Coregulator Buffer H may be shipped frozen or at room temperature. Store at room temperature (20°C to 30°C).
Label Type: __
Quantity: 25 mL
Shipping Condition: Approved for shipment at Room Temperature or on Wet or Dry Ice
Content And Storage:
TR-FRET Coregulator Buffer H may be shipped frozen or at room temperature. Store at room temperature (20°C to 30°C).
Label Type:
__
Quantity:
25 mL
Shipping Condition:
Approved for shipment at Room Temperature or on Wet or Dry Ice