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K1648

Thermo Scientific™ CellSensor™ SIE-blaME-180 Cell Line

Manufacturer: Thermo Scientific™

Select a Size

Pack Size	SKU	Availability	Price
Each of 1	K1648-Each-of-1	In Stock	₹ 9,05,224.80

K1648 - Each of 1

₹ 9,05,224.80

In Stock

Quantity

Base Price: ₹ 9,05,224.80

GST (18%): ₹ 1,62,940.464

Total Price: ₹ 10,68,165.264

Assay Entry

Cell-based beta lactamase reporter gene

Content And Storage

CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.

Quantity

1 Vial

System Type

CellSensor™

Cell State

Dividing Cells

Product Line

CellSensor™

Target Entry

STAT1, STAT3, JAK/STAT (IFN gamma, IL-6/OSM) pathway, JAK2, JAK1

Druggable Target

Signaling Pathway

Related Products

Description

The CellSensor&tarde; SIE-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Sis-Inducible Element (SIE) stably integrated into ME-180 cells
To construct this cell line, the SIE-bla construct was transduced into ME-180 cells by lentivirus
Flow cytometry was used to isolate cells responsive to Interleukin-6 (IL-6)
This cell line is validated for DMSO tolerance, cell number, stimulation time, substrate loading time, as well as Z' and EC50 concentrations of IL-6
The CellSensor™ SIE-bla ME-180 cell line is responsive to IL-6, OSM and IFNγ and can be used to probe the JAK/STAT signaling pathway
This cell line can be adapted for high-throughput screening of agonist or antagonist compound libraries
Candidate drugs can also be tested for dose response against this cell line
Academic and non-profit customers, please inquire for special pricing.

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