Description

• General description: γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean,[1] germinated rice, and in some fermented foods.[2]
• Application: γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats.[3] It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.[4]
• Biochem/physiol Actions: γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions.[1] It is crucial for the normal central nervous system (CNS) functioning.[2] A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects.[1] GABA might show beneficial effects on stress and sleep in humans.[2] γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.[1]