Bleomycin sulfate from Streptomyces verticillus
crystalline, 1.5-2.0 U/mg
Manufacturer: Sigma Aldrich
CAS Number: 9041-93-4
Synonym(S): Blenoxane, Bleo, Blexane
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 15 UNITS | B5507-15-UNITS | In Stock | ₹ 1,06,539.65 |
B5507 - 15 UNITS
In Stock
Quantity
1
Base Price: ₹ 1,06,539.65
GST (18%): ₹ 19,177.137
Total Price: ₹ 1,25,716.787
form
crystalline
Quality Level
200
specific activity
1.5-2.0 U/mg
color
white to off-white
solubility
H2O: 20 mg/mL
cation traces
Cu: ≤0.10%
antibiotic activity spectrum
fungi
Mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
[O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C
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Description
- General description: Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus.[1] It is recommended for use as a cell culture agent at 10-100 μg/mL.
- Application: Bleomycin Sulfate is an atineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
- Biochem/physiol Actions: Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
- Features and Benefits: This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
- Components: This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.
- Caution: This product should be stored at 2-8°C.
- Preparation Note: The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 2 - Muta. 1B - Repr. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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form: crystalline
Quality Level: 200
specific activity: 1.5-2.0 U/mg
color: white to off-white
solubility: H2O: 20 mg/mL
cation traces: Cu: ≤0.10%
antibiotic activity spectrum: fungi
Mode of action: DNA synthesis | interferes
storage temp.: 2-8°C
SMILES string: [O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C
form: liquid
Quality Level: 100
specific activity: __
color: __
solubility: __
cation traces: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: CC(=O)O[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C
form: __
Quality Level: 200
specific activity: __
color: __
solubility: __
cation traces: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: 2-8°C
SMILES string: Cl.CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13
