Fibroblast Growth Factor-8b from mouse

Description

• General description: Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f.[1]
• Application: Fibroblast Growth Factor-8b from mouse has been used-for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs[2]in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED)[3] andin experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene.[4]
• Biochem/physiol Actions: FGF-8b is involved in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4.
• Physical form: Lyophilized from a 0.2μm filtered solution in 20mM MOPS, 0.1M sodium sulfate, 0.02% Brij-35, pH 7 containing 50ug of BSA per 1μg as a carrier protein
• Analysis Note: The biological activity is measured by its ability to stimulate proliferation of NR6R-3T3 fibroblasts.