Description

• General description: Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis.[1] Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.[2]
• Application: Gentamicin solution has been used as an antibiotic component in eukaryotic cell culture[3][4][5][6][7][8] and bacterial culture.[9][10][11]
• Biochem/physiol Actions: Gentamicin is recommended for treating sepsis during emergency treatment.[15] It is an alternate to ceftriaxone for treating genital infection.[16]
• Components: Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.
• Caution: The product is stable at 37° for 5 days and is stored at 2-8°C.