Description

• General description: Glycogen phosphorylase (PYG) exists as brain and muscle isoform. It is expressed in astrocytes and neurons respectively.[1] The PYGM gene is mapped to human chromosome 11q13.1.[2]
• Application: D-(+)-Glucose has been used in cell engineering.[3] It has also been used to perform oral glucose tolerance test.[4]
• Biochem/physiol Actions: Glycogen phosphorylase, muscle associated (PYGM), is an important contributor to glycogenolysis. Down regulation of PYGM gene is observed in schizophrenia.[1] Mutation in PYGM leads to McArdle disease, a glycogen storage disorder.[5] The PYGM gene is significantly associated with energy production.[6]
• Preparation Note: The material may produce a yellowish solution if prepared at a higher concentration than 2g + 15ml.
• Legal Information: Hybri-Max is a trademark of Sigma-Aldrich Co. LLC