Itraconazole
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 84625-61-6
Synonym(S): Oriconazole, R51211, Sporanox
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | I6657-100-MG | In Stock | ₹ 27,517.15 |
I6657 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 27,517.15
GST (18%): ₹ 4,953.087
Total Price: ₹ 32,470.237
Quality Level
200
Assay
≥98% (HPLC)
color
white
solubility
chloroform: 50 mg/mL, clear, colorless
antibiotic activity spectrum
fungi
Mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCC5COC(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI
1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
InChI key
VHVPQPYKVGDNFY-UHFFFAOYSA-N
Other Options
Related Products
Description
- Application: Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It′s different formulations are used to study Candida strains in murine invasive infections[1]. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats[2].
- Biochem/physiol Actions: Itraconazole inhibits cytochrome P-450-dependent enzymes which results in the inhibition of ergosterol synthesis. It does so by interacting with 14-α demethylase, which is a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is a crucial compenent of fungal cell membranes. Therefore, it′s inhibition results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Quality Level: 200
Assay: ≥98% (HPLC)
color: white
solubility: chloroform: 50 mg/mL, clear, colorless
antibiotic activity spectrum: fungi
Mode of action: enzyme | inhibits
storage temp.: 2-8°C
SMILES string: CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCC5COC(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI: 1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
InChI key: VHVPQPYKVGDNFY-UHFFFAOYSA-N
Quality Level: 300
Assay: ≥99% (TLC)
color: white to off-white
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: __
InChI: __
InChI key: __
Quality Level: 300
Assay: ≥99% (TLC)
color: white to off-white
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: __
InChI: __
InChI key: __
