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SRP3236

TPO from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Manufacturer: Sigma Aldrich

Synonym(S): MGDF, Megakaryocyte colony-stimulating factor, Thrombopoietin, c-MPL Ligand

Select a Size

Pack Size SKU Availability Price
10 μG SRP3236-10-μG In Stock ₹ 35,830.80

SRP3236 - 10 μG

₹ 35,830.80

In Stock

Quantity

1

Base Price: ₹ 35,830.80

GST (18%): ₹ 6,449.544

Total Price: ₹ 42,280.344

biological source

mouse

recombinant

expressed in E. coli

Assay

≥98% (HPLC)≥98% (SDS-PAGE)

form

lyophilized

potency

<1.0 ng/mL ED50

mol wt

18.7 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

Description

  • General description: TPO (thrombopoietin) is a hematopoietic cytokine expressed in multiple tissue types. It is predominantly produced by liver and kidney and acts as a ligand for the cell surface receptor c-mpl.[1][2]
  • Biochem/physiol Actions: TPO (thrombopoietin) is the key regulator of thrombopoiesis for platelet lineage. In both mice and humans, inactivation of this gene results in significant decrease in number of mature platelets produced by marrow progenitors.[1] Transgenic mice with increased expression of this protein show progressive fibrosis and osteosclerosis of the bone marrow, as well as histological changes in kidneys, leading to mesangioproliferative glomerulopathy.[2]
  • Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
  • Physical form: Lyophilized from 10 mM Sodium Phosphate, pH 8.0.
  • Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of ?0.5 mg/ml. Slow to dissolve. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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SRP3236

recombinant, expressed in E. coli, ...

biological source:
mouse
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
potency:
<1.0 ng/mL ED50
mol wt:
18.7 kDa
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white

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Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
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mol wt:
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