NovaSyn TG bromo resin

Description

• General description: NovaSyn TG bromo resin is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol [1,2,3], in which the ends of the PEG chains have been bromo functionalized. The 130 μm beads have a narrow size distribution, high diffusion rates and excellent swelling properties across a wide range of solvents from toluene to water, making them ideally suited to the synthesis of serial and parallel libraries by organic solid phase synthesis. This support may be used for the immobilization of alcohols, carboxylic acids, phenols and thiols, or as base support for other linkers [4,5]. Loading of this support can be carried out using the same methods as those previously described for Merrifield resin. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis ResinsLiterature references [1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205. [2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196. [3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113. [4] K. H. Gordon & S. Balasubramanian (2001) Org. Lett., 3, 53. [5] D. Tumelty, et al. (2001) Org. Lett., 3, 83
• Linkage: Replaces: 01-64-0095
• Analysis Note: Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemntal analysis of bromine): 0.20 - 0.40 mmol/gSwelling Volume (in CH₂Cl₂): lot specific result
• Legal Information: NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany