Description

• General description: A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases activity of Ca2+-activated K+ channels. Used as an inhibitor of ATP-dependent enzyme systems.
• Application: Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).
• Warning: Toxicity: Standard Handling (A)
• Reconstitution: Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.
• Other Notes: Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.Chung, S., et al. 1991. Science253, 560.Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.
• Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany