Description

• General description: Cerebrosides are glycosphingolipids with either glucose or galactose as a polar head group. They comprise the major component of the myelin lipids. Cerebrosides are part of non-neural cells including the epithelial cells associated with skin and the digestive system.[1] Cerebrosides are amphipathic in nature.[2]
• Application: Cerebrosides (Brain) has been used: in the coating of coverslips for neurite outgrowth assay of retinal ganglion cells[3]in reconstruction of the apical membrane of Madin-Darby canine kidney (MDCK) cells[4]in the preparation of liposomes to mimic the MDCK cell membrane for permeability studies[5]
• Biochem/physiol Actions: Cerebrosides regulate a variety of physiological processes like cell growth, survival and multiplication. They coordinate membrane trafficking and inhibit apoptosis. Inborn metabolic disorder, Gaucher′s disease is associated with elevated levels of cerebrosides.[6]. Additionally, cerebrosides provide structural support to the membranes and mediate intracellular communication.[2] Accumulation of galactocerebrosides is associated with tumors. It also serves as a receptor for human immune deficiency virus (HIV) glycoprotein.[6] The porcine cerebroside and ganglioside (CPCG) is used in treating neurotoxicity induced by the drug oxaliplatin in digestive system tumors.[7]
• Packaging: 5 mL Amber Glass Screw Cap Vial (131303P-25mg)