850165P

18:0-20:4 PI(4,5)P2

Manufacturer: Sigma Aldrich

CAS Number: 799268-59-0

Synonym(S): 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-[phosphoinositol-4,5-bisphosphate] (ammonium salt); PIP2[4′,5′](18:0/20:4(5Z,8Z,11Z,14Z))

Select a Size

Pack Size SKU Availability Price
100 μG 850165P-100-μG In Stock ₹ 25,211.43
1 MG 850165P-1-MG In Stock ₹ 79,531.28
500 μG 850165P-500-μG In Stock ₹ 1,00,369.40
5 MG 850165P-5-MG In Stock ₹ 3,18,135.93

850165P - 100 μG

₹ 25,211.43

In Stock

Quantity

1

Base Price: ₹ 25,211.43

GST (18%): ₹ 4,538.057

Total Price: ₹ 29,749.487

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850165P-100ug))pkg of 1 × 500 μg (with stopper and crimp cap (850165P-500ug))

manufacturer/tradename

Avanti Polar Lipids 850165P

lipid type

cardiolipinsphospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

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Description

  • General description: Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
  • Application: 18:0-20:4 PI(4,5)P2 or 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt) has been used:in cryo-electron microscopy (cryo-EM) grid preparation[2]in host 1-O-1-(Z)-octadecenyl-2-arachidonoyl-sn-glycero-3-phosphocholine (plasmenyl-SAPC) small unilamellar vesicles (SUVs) in the presence of H2O2 to activate cyt c plasmalogenase activity[1]to study whether acyl chain types affect phosphatidylinositol 4,5-bisphosphate (PIP2) cluster formation[3]
  • Packaging: 2 mL Amber Serum Vial with Stopper and Crimp Cap (850165P-100ug)

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Assay:
>99% (TLC)

form:
powder

packaging:
pkg of 1 × 100 μg (with stopper and crimp cap (850165P-100ug))pkg of 1 × 500 μg (with stopper and crimp cap (850165P-500ug))

manufacturer/tradename:
Avanti Polar Lipids 850165P

lipid type:
cardiolipinsphospholipids

shipped in:
dry ice

storage temp.:
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SMILES string:
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

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form:
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packaging:
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manufacturer/tradename:
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lipid type:
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shipped in:
dry ice

storage temp.:
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SMILES string:
CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.O=C(C1=CC=C(/N=N/C2=CC=C(N(C)C)C=C2)C=C1)NCCOCCCCO[C@H]([C@H]([C@@H]3O)OP(O)(O)=O)[C@H](OP(OC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCNC(C4=CC(C5=C6C=CC(C=C6OC7=C5C=CC(O)=C7)=O)=C(C(O)=O)C=C4)=O)=O)(O)=O)[C@H](O)[C@@H]3O.O=P(O)=O

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lipid type:
phospholipidscardiolipins

shipped in:
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storage temp.:
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[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+]

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form:
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packaging:
pkg of 1 × 100 μg (with stopper and crimp cap (850182P-100ug))pkg of 1 × 500 μg (with stopper and crimp cap (850182P-500ug))

manufacturer/tradename:
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shipped in:
dry ice

storage temp.:
−20°C

SMILES string:
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+]