Description

• General description: Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants.[1] Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine[2] and regulates S1P levels.[3] It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.[4]
• Application: Sphingosine-1-Phosphate (d18:1) has been used:as an internal standard in high performance liquid chromatography (HPLC) for the quantification of plasma lipid sphingosine-1-phosphate(S1P)[5]to evaluate its chemotactic response of auto reactive immature B cells[6]to test its effect on autophagy and preconditioning in oxygen and glucose deprived neurons[3]
• Biochem/physiol Actions: Sphingosine 1-phosphate (S1P) is a signaling molecule and an intracellular messenger, crucial for the physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes.[2] S1P regulates skin dendritic cells and keratinocytes, and its anti-inflammatory functionality is useful in treating atopic dermatitis.[4] S1P coordinates T lymphocytes circulation in lymph, plasma and tissue by interacting with G-protein coupled receptors (GPCRS).[6] S1P is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1−5).[7]
• Packaging: 5 mL Amber Glass Screw Cap Vial (860492P-1mg)