oxPAPC

Description

• General description: Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is a mixture of oxidized phospholipid[1] and a bioactive constituent of oxidized low-density lipoproteins (LDLs).[2]
• Application: Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is suitable for use to stimulate murine alveolar macrophages in vitro.[3] It is also suitable for use to study its effects on human aortic endothelial cell metabolic reprogramming.[1]
• Biochem/physiol Actions: Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) show barrier-protective effects on human pulmonary endothelial monolayers.[2] This lipid induce endothelial dysfunction by stimulating both pro- and anti-inflammatory pathways.[1] OxPAPC is highly accumulated in atherosclerotic lesions and other sites of chronic inflammation.[4]
• Packaging: 5 mL Clear Glass Sealed Ampule (870604P-500ug)