Calcium Ionophore A23187
≥98% (TLC), powder
Manufacturer: Sigma Aldrich
CAS Number: 52665-69-7
Synonym(S): Calcimycin, Antibiotic A 23187, Calimycin
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | C7522-1-MG | In Stock | ₹ 7,382.65 |
| 5 MG | C7522-5-MG | In Stock | ₹ 17,482.38 |
| 10 MG | C7522-10-MG | In Stock | ₹ 27,744.48 |
| 50 MG | C7522-50-MG | In Stock | ₹ 1,02,014.80 |
C7522 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 7,382.65
GST (18%): ₹ 1,328.877
Total Price: ₹ 8,711.527
sterility
non-sterile
Quality Level
300
Assay
≥98% (TLC)
form
powder
color
white to light yellow
solubility
ethanol: 5 mg/mL (with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)DMSO: 50 mg/mL (with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)
antibiotic activity spectrum
Gram-positive bacteriafungi
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
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Description
- General description: Calcium ionophore A23187 is a carboxylic acid antibiotic with weak in vitro activity against Gram-positive organisms. It increases the potential of divalent ions to cross biological membranes, thus it acts as an ionophore. Calcium ionophore A23187 specifically forms stable 2:1 complex with divalent cations, rendering these ions soluble in ordinary organic solvents. Since calcium ionophore A23187 is commonly used to increase intracellular Ca2+ levels in intact cells, it acts as an uncoupler of oxidative phosphorylation and an inhibitor of mitochondrial adenosine triphosphatase (ATPase) activity. Calcium Ionophore A23187 is a potent inducer of phosphorylation of Toxoplasma eukaryotic initiation factor-2α (eIF2α). It also induces apoptosis in mouse lymphoma cell line (S49)7 but also has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells. Calcium ionophore A23187 is widely used as artificial activating substances for human oocytes.
- Application: Calcium ionophore A23187 has been used:as an endoplasmic reticulum (ER) stress inducer to study its effect on the expression of the toxoplasma unfolded protein response (UPR) genesfor the induction of the acrosome reactionin skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity assay
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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sterility: non-sterile
Quality Level: 300
Assay: ≥98% (TLC)
form: powder
color: white to light yellow
solubility: ethanol: 5 mg/mL (with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)DMSO: 50 mg/mL (with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)
antibiotic activity spectrum: Gram-positive bacteriafungi
Mode of action: cell membrane | interferes
storage temp.: 2-8°C
SMILES string: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
sterility: __
Quality Level: 300
Assay: ≥98%
form: crystals
color: white
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: __
sterility: __
Quality Level: 200
Assay: ≥99%
form: liquid
color: colorless
solubility: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: __
