D141
Digitonin
Used as non-ionic detergent
Manufacturer: Sigma Aldrich
CAS Number: 11024-24-1
Synonym(S): Digitin
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | D141-100-MG | In Stock | ₹ 11,236.35 |
| 500 MG | D141-500-MG | In Stock | ₹ 36,285.40 |
D141 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 11,236.35
GST (18%): ₹ 2,022.543
Total Price: ₹ 13,258.893
biological source
plant seeds (Digitalis purpurea)
Quality Level
200
form
powder
optical activity
[α]20/D −54°, c = 2.8 in methanol(lit.)
mol wt
micellar avg mol wt 70,000
aggregation number
60
impurities
<6.0% water
CMC
<0.5 mM (20-25°C)<0.5 mM (20-25°C)
mp
230-240 °C (dec.) (lit.)
solubility
H2O: ~5 % (w/v) (solubilized by heating to 95 °C - 98 °C and then cooling to room temp.)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Medchemexpress LLC HY-N4000 25mg Medchemexpress, Digitonin CAS:11024-24-1 Purity:>98% | -- | ₹ 3,284.10 | ||
Sigma Aldrich Fine Chemicals Biosciences Digitonin ~50% (TLC) | 11024-24-1 | MFCD00077729 | 1G | -- | ₹ 57,351.60 | ||
Sigma Aldrich Fine Chemicals Biosciences Digitonin | 11024-24-1 | MFCD00077729 | 500mg | -- | ₹ 30,963.10 | ||
Digitonin | -- | ₹ 55,521.43 - ₹ 1,31,458.80 | ||
11024-24-1 | DIGITONIN | -- | ₹ 3,204.00 - ₹ 16,287.00 |
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Description
- General description: Digitonin, a steroidal saponin extracted from the purple foxglove plant (Digitalis purpurea), stands as a versatile non-ionic detergent crucial for cell biology and biochemical research. Its unique attributes position it as a valuable asset in the exploration of cellular membranes, membrane proteins, and intracellular components. Digitonin′s key properties and applications include its ability to solubilize membrane-bound proteins effectively while preserving their native conformation, making it an ideal tool for studying membrane protein interactions and activities.Moreover, Digitonin selectively permeabilizes the cholesterol-rich plasma membrane, leaving organelle membranes intact. This feature facilitates the extraction and purification of specific organelles, contributing to the study of their functions and roles in cellular processes. The detergent′s capability to permeabilize diverse cell types allows the study of intracellular components and processes by introducing molecules, antibodies, or enzymes into cells. Additionally, Digitonin finds application in immunocytochemistry experiments, enabling the labeling and detection of intracellular proteins and structures.
- Application: Digitonin has been used along with permeabilization buffer for cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) stimulation in cells.
- Biochem/physiol Actions: Digitonin plays a key role in permeabilizing cell membranes. It is capable of lysing eukaryotic cells but not bacterial membranes. It is also used to solubilize membrane components. It helps to create pores by interacting specifically with cholesterol in the membrane. It is preferred in biotechnology due to its mild detergency. This membrane-active compound act with doxorubicin against multi-drug resistant cancer cells.
- Features and Benefits: Highly versatile compound for your cell biology and biochemical research
- Quality: Preparation is free of water-insoluble constituents.
- Other Notes: For additional information on our range of Biochemicals, please complete this form.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - STOT RE 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves