M6159

α2-Macroglobulin from human plasma

BioUltra, ≥98% (SDS-PAGE)

Manufacturer: Sigma Aldrich

CAS Number: 1631137-21-7

Synonym(S): α2-M

Select a Size

Pack Size SKU Availability Price
1 MG M6159-1-MG In Stock ₹ 31,168.80
5 MG M6159-5-MG In Stock ₹ 1,05,006.00
10 MG M6159-10-MG In Stock ₹ 1,82,961.30

M6159 - 1 MG

₹ 31,168.80

In Stock

Quantity

1

Base Price: ₹ 31,168.80

GST (18%): ₹ 5,610.384

Total Price: ₹ 36,779.184

biological source

human plasma

Quality Level

200

product line

BioUltra

Assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

~720 kDa (four glycoprotein subunits)

composition

Protein, 15-30% biuret

technique(s)

inhibition assay: suitable

solubility

water: soluble 10 mg protein/mL, clear, colorless

UniProt accession no.

P01023

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Description

  • Application: α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease.[1] It was also used in the control of the classical and the MBL pathway of complement activation.[2]
  • Biochem/physiol Actions: α2-Macroglobulin (α2M) is a multifunctional protein that is a broad spectrum protease inhibitor. α2M is a large homotetrameric glycoprotein (720 kDa) that is connected by disulfide-linked dimers which non-covalently interact to give the quaternary structure. α2M is found in normal plasma at a concentration of 220-230 mg/dl accounting for 3-5% of the total plasma protein.[3]
  • Packaging: Package size based on protein content
  • Physical form: Lyophilized from 0.02 M Tris, 0.13 M glycine, pH 8.0, and 0.08 M trehalose
  • Analysis Note: Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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human plasma

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~720 kDa (four glycoprotein subunits)

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inhibition assay: suitable

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water: soluble 10 mg protein/mL, clear, colorless

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P01023

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