MAK196
Malate Dehydrogenase Assay Kit
Sufficient for 100 Colorimetric tests
Manufacturer: Sigma Aldrich
Synonym(S): MDH Activity Assay Kit
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 KIT | MAK196-1-KIT | In Stock | ₹ 61,260.90 |
MAK196 - 1 KIT
In Stock
Quantity
1
Base Price: ₹ 61,260.90
GST (18%): ₹ 11,026.962
Total Price: ₹ 72,287.862
detection method
colorimetric
relevant disease(s)
neurological disorders
storage temp.
−20°C
Gene Information
human ... MDH1(4190) , MDH1B(130752) , MDH2(4191) mouse ... MDH1(17449) , MDH1B(76668) , MDH2(17448) rat ... MDH1(24551) , MDH1B(316444) , MDH2(81829)
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Description
- General description: Malate dehydrogenase (MDH; EC 1.1.1.37) is an NAD oxidoreductase that catalyzes the NAD/NADH-dependent interconversion of malate and oxalacetate. This reaction is critical to maintain the malate/aspartate shuttle across the mitochondrial membrane and Krebs tricarboxylic acid cycle in the mitochondrial matrix. Increased MDH activity has been observed in neurodegenerative diseases such as Alzheimer′s disease.
- Application: Malate Dehydrogenase Assay Kit has been used in LDH (lactate dehydrogenase) and malate dehydrogenase (MDH1) assays.[1] It has also been used to estimate isocitrate dehydrogenase[2] and succinate dehydrogenase activities.[3]
- Suitability: Suitable for the detection of Malate Dehydrogenase activity in a variety of biological samples such as cell and tissue culture supernatants and purified mitochondria.
- Principle: The Malate Dehydrogenase Assay Kit provides a simple and sensitive procedure for measuring MDH activity in a variety of tissues, cell cultures, and isolated mitochondria. MDH activity is determined by generating a product with absorbance at 450 nm proportional to the enzymatic activity present. One unit of MDH is the amount of enzyme that generates 1.0 μmole of NADH per minute at 37 °C and pH 9.5.
SAFETY INFORMATION
Signal Word
Danger
Hazard Statements
Precautionary Statements
P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 3
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detection method: colorimetric
relevant disease(s): neurological disorders
storage temp.: −20°C
Gene Information: human ... MDH1(4190) , MDH1B(130752) , MDH2(4191) mouse ... MDH1(17449) , MDH1B(76668) , MDH2(17448) rat ... MDH1(24551) , MDH1B(316444) , MDH2(81829)
detection method:
colorimetric
relevant disease(s):
neurological disorders
storage temp.:
−20°C
Gene Information:
human ... MDH1(4190) , MDH1B(130752) , MDH2(4191) mouse ... MDH1(17449) , MDH1B(76668) , MDH2(17448) rat ... MDH1(24551) , MDH1B(316444) , MDH2(81829)
detection method: colorimetric
relevant disease(s): __
storage temp.: −20°C
Gene Information: __
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relevant disease(s):
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storage temp.:
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detection method: fluorometric
relevant disease(s): cardiovascular diseases
storage temp.: 2-8°C
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fluorometric
relevant disease(s):
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