T0261

Thiamphenicol

Manufacturer: Sigma Aldrich

CAS Number: 15318-45-3

Synonym(S): Raceophenidol, Thiophenicol, D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide

Select a Size

Pack Size SKU Availability Price
1 G T0261-1-G In Stock ₹ 6,798.10
5 G T0261-5-G In Stock ₹ 13,401.35
25 G T0261-25-G In Stock ₹ 53,605.40

T0261 - 1 G

₹ 6,798.10

In Stock

Quantity

1

Base Price: ₹ 6,798.10

GST (18%): ₹ 1,223.658

Total Price: ₹ 8,021.758

form

powder

Quality Level

100

color

white to off-white

solubility

ethanol: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteriaGram-positive bacteria

Mode of action

protein synthesis | interferes

SMILES string

CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl

InChI

1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1

InChI key

OTVAEFIXJLOWRX-NXEZZACHSA-N

Other Options

Image Product Name Manufacturer Price Range
11-101-3225
Thiamphenicol, ≥99% (HPLC), MilliporeSigma™ Supelco™
MilliporeSigma Supelco ₹ 8,470.44
16715
Thiamphenicol
Supelco ₹ 6,949.65
T1100000
Thiamphenicol
Sigma Aldrich ₹ 14,267.35
CS-2593
Thiamphenicol
ChemScene ₹ 5,989.20 - ₹ 21,390.00
AI37159
15318-45-3 | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
A2B Chem ₹ 1,540.08 - ₹ 24,127.92

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Description

  • General description: Chemical structure: phenicole
  • Application: Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea[1][2]. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered[3].
  • Biochem/physiol Actions: Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.
  • Packaging: 1G,5G,25G
  • Other Notes: Keep container tightly closed in a dry and well-ventilated place.

SAFETY INFORMATION

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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form:
powder

Quality Level:
100

color:
white to off-white

solubility:
ethanol: soluble 50 mg/mL

antibiotic activity spectrum:
Gram-negative bacteriaGram-positive bacteria

Mode of action:
protein synthesis | interferes

SMILES string:
CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl

InChI:
1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1

InChI key:
OTVAEFIXJLOWRX-NXEZZACHSA-N

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[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCCS(=O)([O-])=O)=O.[Na+]

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1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

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BHTRKEVKTKCXOH-LBSADWJPSA-N

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[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

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__

InChI key:
__