U211000
DMT-2′O-TBDMS-rU Phosphoramidite
Manufacturer: Sigma Aldrich
CAS Number: 118362-03-1
Synonym(S): 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-uridine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], DMT-2′-O-TBDMS-rU amidite
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 G | U211000-100-G | In Stock | ₹ 8,79,022.48 |
| 500 G | U211000-500-G | In Stock | ₹ 39,11,483.85 |
U211000 - 100 G
In Stock
Quantity
1
Base Price: ₹ 8,79,022.48
GST (18%): ₹ 1,58,224.046
Total Price: ₹ 10,37,246.526
biological source
non-animal source (no BSE/TSE risk)
Quality Level
300
product line
Proligo Reagents
Assay
≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form
powder
impurities
≤0.3 wt. % water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3 wt. % residual Solvent content
color
white to off-white
λ
conforms (UV/VIS Identity)
suitability
conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile
base: uridinebase protecting group: none2' protecting group: TBDMS5' protecting group: DMTdeprotection: fast/standard
Other Options
Description
- General description: DMT-2′O-TBDMS-rU Phosphoramidite belongs to the group of 2′O-TBDMS RNA Phosphoramidites.
- Application: RNA interference (RNAi) has become a popular tool for the sequence-specific inhibition of gene expression and can be used in target validation and other drug development techniques. The most convenient method to provide sequence-specific RNA oligonucleotides is a chemical synthesis on a solid support with RNA phosphoramidites and RNA CPG, analogous to DNA synthesis.
- Features and Benefits: Industry-standard 2′O-TBDMS protective group Consistent lot-to-lot purity and performance Compatible with deprotection methods based on methylamine or AMA Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as activator; best results are obtained with Activator 42 Capping with standard acetic anhydride capping reagent rather than with Fast Deprotection Cap AManufactured under a certified ISO 9001 quality system
- Other Notes: The unique properties of RNA have stimulated the development of a variety of applications in diagnostics and therapeutics, as well as in basic molecular biology research where RNA can be used as: Catalytic agents (ribozymes) Affinity ligands (aptamers) Agents to induce gene silencing (RNA interference)
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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biological source: non-animal source (no BSE/TSE risk)
Quality Level: 300
product line: Proligo Reagents
Assay: ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form: powder
impurities: ≤0.3 wt. % water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3 wt. % residual Solvent content
color: white to off-white
λ: conforms (UV/VIS Identity)
suitability: conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile: base: uridinebase protecting group: none2' protecting group: TBDMS5' protecting group: DMTdeprotection: fast/standard
biological source:
non-animal source (no BSE/TSE risk)
Quality Level:
300
product line:
Proligo Reagents
Assay:
≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form:
powder
impurities:
≤0.3 wt. % water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3 wt. % residual Solvent content
color:
white to off-white
λ:
conforms (UV/VIS Identity)
suitability:
conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile:
base: uridinebase protecting group: none2' protecting group: TBDMS5' protecting group: DMTdeprotection: fast/standard
biological source: non-animal source (no BSE/TSE risk)
Quality Level: 300
product line: Proligo Reagents
Assay: ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form: powder
impurities: ≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3% residual Solvent content
color: white to off-white
λ: conforms (UV/VIS Identity)
suitability: conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile: __
biological source:
non-animal source (no BSE/TSE risk)
Quality Level:
300
product line:
Proligo Reagents
Assay:
≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form:
powder
impurities:
≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3% residual Solvent content
color:
white to off-white
λ:
conforms (UV/VIS Identity)
suitability:
conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile:
__
biological source: non-animal source (no BSE/TSE risk)
Quality Level: 300
product line: Proligo Reagents
Assay: ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form: powder
impurities: ≤0.3% mU2 (reversed phase HPLC, Hydrolysate)≤0.3% mU3 (reversed phase HPLC, DMT-rme)≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (redox titration)≤1.0% mU1 (reversed phase HPLC, DMT-rUme-DMT)≤3% residual Solvent content
color: white to off-white
λ: __
suitability: conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile: __
biological source:
non-animal source (no BSE/TSE risk)
Quality Level:
300
product line:
Proligo Reagents
Assay:
≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form:
powder
impurities:
≤0.3% mU2 (reversed phase HPLC, Hydrolysate)≤0.3% mU3 (reversed phase HPLC, DMT-rme)≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (redox titration)≤1.0% mU1 (reversed phase HPLC, DMT-rUme-DMT)≤3% residual Solvent content
color:
white to off-white
λ:
__
suitability:
conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile:
__
biological source: non-animal source (no BSE/TSE risk)
Quality Level: 300
product line: Proligo Reagents
Assay: ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form: powder
impurities: ≤0.1% single unspecified Impurity (reversed phase HPLC)≤0.3% mU2 (reversed phase HPLC, Hydrolysate)≤0.3% mU3 (reversed phase HPLC, DMT-rme)≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤1.0% mU1 (reversed phase HPLC, DMT-rUme-DMT)≤3% residual Solvent content
color: white to off-white
λ: conforms (UV/VIS Identity)
suitability: conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile: __
biological source:
non-animal source (no BSE/TSE risk)
Quality Level:
300
product line:
Proligo Reagents
Assay:
≥99% (31P-NMR)≥99.0% (reversed phase HPLC)
form:
powder
impurities:
≤0.1% single unspecified Impurity (reversed phase HPLC)≤0.3% mU2 (reversed phase HPLC, Hydrolysate)≤0.3% mU3 (reversed phase HPLC, DMT-rme)≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤1.0% mU1 (reversed phase HPLC, DMT-rUme-DMT)≤3% residual Solvent content
color:
white to off-white
λ:
conforms (UV/VIS Identity)
suitability:
conforms to structure for H-NMRconforms to structure for LC-MS
nucleoside profile:
__