Description

• General description: 1,3,5-tris(trifluoromethyl)benzene is a tri-substituted benzene. It has been synthesized by reacting benzene-1,3,5-tricarboxylic acid with SF4.[1] Reports suggest that 1,3,5-tris(trifluoromethyl)benzene is a nonanesthetics and shows convulsant properties.[2] Its vapor absorption spectra and corresponding solution spectra has been investigated.[3] Its reaction with methyl lithium has been analyzed using semiempirical reaction modelling.[4]
• Application: 1,3,5-tris(trifluoromethyl)benzene was used as a starting material in the synthesis of bis(2,4,6-tris(trifluoromethyl)phenyl)chloropnictines.[5]It may be used as a starting material in the synthesis of 2,4,6-tris(trifluoromethyl)benzoic acid by reacting with n-butyllithium and carbon dioxide[6] and in the synthesis of lithio derivative, via direct metalation with n-butyllithium.[1]