807745

APN-COCI

Manufacturer: Sigma Aldrich

Synonym(S): 4-(cyanoethynyl)benzoyl chloride

Select a Size

Pack Size SKU Availability Price
50 MG 807745-50-MG In Stock ₹ 10,002.30

807745 - 50 MG

₹ 10,002.30

In Stock

Quantity

1

Base Price: ₹ 10,002.30

GST (18%): ₹ 1,800.414

Total Price: ₹ 11,802.714

form

powder

Quality Level

100

reaction suitability

reagent type: cross-linking reagent

storage temp.

2-8°C

SMILES string

N#CC#CC1=CC=C(C(Cl)=O)C=C1

InChI

1S/C10H4ClNO/c11-10(13)9-5-3-8(4-6-9)2-1-7-12/h3-6H

InChI key

OWNJCJKKKZXTIX-UHFFFAOYSA-N

Description

  • Application: APN-COCl is a bifunctional reagent appropriate for the introduction of APN function.
  • Other Notes: The coupling between an amine and APN-COCl should be performed in dry organic solvents (e.g. THF) in the presence of a base (e.g. TEA). The resulting conjugate can be readily coupled with thiol-containing biomolecules using the following protocol:Dissolve the protein in the appropriate buffer with pH 6.5-9.0 (e.g. PBS) at 1-10 mg/mL concentration.Apply the appropriate amount of the stock solution of the APN-labeled molecule (1-5 molar eq. per free cysteine residue).Incubate at room temperature for 2 hours.If necessary, purify the protein conjugate using size exclusion chromatography or ultrafiltration.

SAFETY INFORMATION

Pictograms

GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H314

Precautionary Statements

P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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reagent type: cross-linking reagent

storage temp.:
2-8°C

SMILES string:
N#CC#CC1=CC=C(C(Cl)=O)C=C1

InChI:
1S/C10H4ClNO/c11-10(13)9-5-3-8(4-6-9)2-1-7-12/h3-6H

InChI key:
OWNJCJKKKZXTIX-UHFFFAOYSA-N

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