(S,R,S)-AHPC-PEG3-Alkyne
≥95%
Manufacturer: Sigma Aldrich
CAS Number: 2374122-30-0
Synonym(S): (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 901533-50-MG | In Stock | ₹ 52,869.30 |
901533 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 52,869.30
GST (18%): ₹ 9,516.474
Total Price: ₹ 62,385.774
ligand
VH032
Quality Level
100
Assay
≥95%
form
powder or crystals
reaction suitability
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group
alkyne
storage temp.
2-8°C
SMILES string
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCCOCC#C)=O)=O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | (S,R,S)-AHPC-CO-PEG3-propargyl | Aaron Chemicals LLC | -- | |
 | (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | ChemScene | ₹ 12,662.88 - ₹ 1,68,382.08 |
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Description
- Application: Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VH032
Quality Level: 100
Assay: ≥95%
form: powder or crystals
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: alkyne
storage temp.: 2-8°C
SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCCOCC#C)=O)=O
ligand: VH032
Quality Level: 100
Assay: ≥95%
form: powder
reaction suitability: reactivity: amine reactivereagent type: ligand-linker conjugate
functional group: carboxylic acid
storage temp.: 2-8°C
SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NCCCCCCC(O)=O)=O.Cl
ligand: __
Quality Level: __
Assay: __
form: liquid
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: __