901873
(S,R,S)-AHPC-PEG6-Alkyne
Manufacturer: Sigma Aldrich
Synonym(S): (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16,19,22-hexaoxa-3-azapentacos-24-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 901873-50-MG | In Stock | ₹ 62,341.18 |
901873 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 62,341.18
GST (18%): ₹ 11,221.412
Total Price: ₹ 73,562.592
ligand
VH032
form
powder
reaction suitability
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group
alkyne
storage temp.
2-8°C
SMILES string
O=C(CCOCCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
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Description
- Application: Protein degrader building block (S,R,S)-AHPC-PEG6-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VH032
form: powder
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: alkyne
storage temp.: 2-8°C
SMILES string: O=C(CCOCCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
ligand:
VH032
form:
powder
reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group:
alkyne
storage temp.:
2-8°C
SMILES string:
O=C(CCOCCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
ligand: __
form: powder
reaction suitability: __
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SMILES string: __
ligand:
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form:
powder
reaction suitability:
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SMILES string:
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ligand: __
form: powder
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: __
ligand:
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form:
powder
reaction suitability:
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functional group:
__
storage temp.:
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SMILES string:
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ligand: __
form: powder or crystals
reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reactionreaction type: Heck Reactionreaction type: Hiyama Couplingreaction type: Negishi Couplingreaction type: Sonogashira Couplingreaction type: Stille Couplingreaction type: Suzuki-Miyaura Couplingreagent type: catalystreaction type: Cross Couplingsreagent type: ligand
functional group: phosphine
storage temp.: __
SMILES string: CC(C)c1cc(C(C)C)c(c(c1)C(C)C)-c2ccccc2P(C(C)(C)C)C(C)(C)C
ligand:
__
form:
powder or crystals
reaction suitability:
reaction type: Buchwald-Hartwig Cross Coupling Reactionreaction type: Heck Reactionreaction type: Hiyama Couplingreaction type: Negishi Couplingreaction type: Sonogashira Couplingreaction type: Stille Couplingreaction type: Suzuki-Miyaura Couplingreagent type: catalystreaction type: Cross Couplingsreagent type: ligand
functional group:
phosphine
storage temp.:
__
SMILES string:
CC(C)c1cc(C(C)C)c(c(c1)C(C)C)-c2ccccc2P(C(C)(C)C)C(C)(C)C