904813

(S,R,S)-AHPC-PEG2-azide

Manufacturer: Sigma Aldrich

CAS Number: 2010159-45-0

Synonym(S): (2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate

Select a Size

Pack Size SKU Availability Price
50 MG 904813-50-MG In Stock ₹ 61,800.00

904813 - 50 MG

₹ 61,800.00

In Stock

Quantity

1

Base Price: ₹ 61,800.00

GST (18%): ₹ 11,124.00

Total Price: ₹ 72,924.00

ligand

VH032

Assay

≥95%

form

solid

reaction suitability

reaction type: click chemistryreagent type: ligand-linker conjugate

functional group

azide

storage temp.

2-8°C

SMILES string

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O

Other Options

Image Product Name Manufacturer Price Range
CS-7735
(S,R,S)-AHPC-PEG2-N3
ChemScene ₹ 17,112.00 - ₹ 2,66,604.96
AX64042
2010159-45-0 | E3 ligase Ligand-Linker Conjugates 13
A2B Chem ₹ 2,224.56 - ₹ 23,956.80

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Description

  • Application: Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
  • Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationImpact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor ScaffoldsStructural basis of PROTAC cooperative recognition for selective protein degradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
  • Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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ligand:
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Assay:
≥95%

form:
solid

reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate

functional group:
azide

storage temp.:
2-8°C

SMILES string:
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O

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Sigma Aldrich

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ligand:
VH032

Assay:
≥95%

form:
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reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate

functional group:
azide

storage temp.:
2-8°C

SMILES string:
O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCN=[N+]=[N-]

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reaction suitability:
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functional group:
azide

storage temp.:
2-8°C

SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCCCCOCCCCCCN=[N+]=[N-])=O)=O)NC1=O