904813
(S,R,S)-AHPC-PEG2-azide
Manufacturer: Sigma Aldrich
CAS Number: 2010159-45-0
Synonym(S): (2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 904813-50-MG | In Stock | ₹ 61,800.00 |
904813 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 61,800.00
GST (18%): ₹ 11,124.00
Total Price: ₹ 72,924.00
ligand
VH032
Assay
≥95%
form
solid
reaction suitability
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group
azide
storage temp.
2-8°C
SMILES string
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | (S,R,S)-AHPC-PEG2-N3 | ChemScene | ₹ 17,112.00 - ₹ 2,66,604.96 | |
 | 2010159-45-0 | E3 ligase Ligand-Linker Conjugates 13 | A2B Chem | ₹ 2,224.56 - ₹ 23,956.80 |
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Description
- Application: Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationImpact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor ScaffoldsStructural basis of PROTAC cooperative recognition for selective protein degradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: VH032
Assay: ≥95%
form: solid
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: azide
storage temp.: 2-8°C
SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O
ligand:
VH032
Assay:
≥95%
form:
solid
reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group:
azide
storage temp.:
2-8°C
SMILES string:
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCN=[N+]=[N-])=O)=O
ligand: __
Assay: ≥95%
form: powder
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: __
ligand:
__
Assay:
≥95%
form:
powder
reaction suitability:
__
functional group:
__
storage temp.:
__
SMILES string:
__
ligand: VH032
Assay: ≥95%
form: liquid
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: azide
storage temp.: 2-8°C
SMILES string: O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCN=[N+]=[N-]
ligand:
VH032
Assay:
≥95%
form:
liquid
reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group:
azide
storage temp.:
2-8°C
SMILES string:
O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCOCCOCCOCCOCCCCCCN=[N+]=[N-]
ligand: pomalidomide
Assay: ≥95%
form: powder or crystals
reaction suitability: reaction type: click chemistryreagent type: ligand-linker conjugate
functional group: azide
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCCCCOCCCCCCN=[N+]=[N-])=O)=O)NC1=O
ligand:
pomalidomide
Assay:
≥95%
form:
powder or crystals
reaction suitability:
reaction type: click chemistryreagent type: ligand-linker conjugate
functional group:
azide
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCCCCOCCCCCCN=[N+]=[N-])=O)=O)NC1=O