(S,R,S)-AHPC-PEG2-butyl chloride
Manufacturer: Sigma Aldrich
CAS Number: 1835705-57-1
Synonym(S): (2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-2-2-6-Cl, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 905399-50-MG | In Stock | ₹ 44,382.50 |
905399 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 44,382.50
GST (18%): ₹ 7,988.85
Total Price: ₹ 52,371.35
ligand
VH032
Assay
≥95%
form
liquid
reaction suitability
reactivity: sulfuryl reactivereagent type: ligand-linker conjugate
functional group
alkyl halide
storage temp.
2-8°C
SMILES string
ClCCCCCCOCCOCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 1835705-57-1 | E3 ligase ligand-linker conjugates 10 | A2B Chem | ₹ 32,427.24 - ₹ 4,22,238.60 |
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Description
- Application: Protein degrader builiding block (S,R,S)-AHPC-PEG2-Butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationModular PROTAC Design for the Degradation of Oncogenic BCR-ABLTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VH032
Assay: ≥95%
form: liquid
reaction suitability: reactivity: sulfuryl reactivereagent type: ligand-linker conjugate
functional group: alkyl halide
storage temp.: 2-8°C
SMILES string: ClCCCCCCOCCOCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
ligand: __
Assay: __
form: viscous liquid
reaction suitability: __
functional group: __
storage temp.: 2-8°C
SMILES string: __
ligand: __
Assay: __
form: viscous liquid
reaction suitability: __
functional group: __
storage temp.: 2-8°C
SMILES string: __
