(S,R,S)-AHPC-PEG2-butyl CO2H
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): (S,R,S)-AHPC-2-2-6-acid, 7-(2-(2-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)ethoxy)heptanoic acid, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 910600-50-MG | In Stock | ₹ 44,400.00 |
910600 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 44,400.00
GST (18%): ₹ 7,992.00
Total Price: ₹ 52,392.00
ligand
VH032
Assay
≥95%
form
crystals
reaction suitability
reactivity: amine reactivereagent type: ligand-linker conjugate
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCC(O)=O.Cl
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Description
- Application: Protein degrader builiding block (S,R,S)-AHPC-PEG2-butyl CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Partial PROTACs for Targeted Protein DegradationBuilding PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VH032
Assay: ≥95%
form: crystals
reaction suitability: reactivity: amine reactivereagent type: ligand-linker conjugate
functional group: carboxylic acid
storage temp.: 2-8°C
SMILES string: O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCC(O)=O.Cl
ligand: __
Assay: __
form: liquid
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: __
ligand: __
Assay: ≥80%
form: powder
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: __
